|
Diabetes Mellitus, Insulin-Dependent
|
0.310 |
Biomarker
|
disease |
BEFREE |
Conversely, both IL-20 and transforming growth factor (TGF-β) decreased in T1D-EV<sup>+</sup> versus EV<sup>-</sup> , while IL-4, -6 and -13 did not show any changes.
|
28640379 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.310 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Kidney Failure, Acute
|
0.310 |
Biomarker
|
disease |
CTD_human |
We analyzed the expression of IL-20 and its receptor (R) in the kidneys of rats with HgCl(2)-induced acute renal failure.
|
18496552 |
2008 |
|
Kidney Failure, Acute
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We analyzed the expression of IL-20 and its receptor (R) in the kidneys of rats with HgCl(2)-induced acute renal failure.
|
18496552 |
2008 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
Our study established increased risk for MDD related to the IL20 and IL24 haplotype and suggests that cytokines may contribute to the pathogenesis of MDD.
|
19087313 |
2008 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Our study established increased risk for MDD related to the IL20 and IL24 haplotype and suggests that cytokines may contribute to the pathogenesis of MDD.
|
19087313 |
2008 |
|
Unipolar Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder.
|
19087313 |
2008 |
|
Diabetes, Autoimmune
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Brittle diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure.
|
18496552 |
2008 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure.
|
18496552 |
2008 |
|
Diabetes Mellitus, Ketosis-Prone
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Diabetes Mellitus, Sudden-Onset
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
|
19430480 |
2009 |
|
Kidney Failure, Chronic
|
0.200 |
Biomarker
|
disease |
RGD |
Interleukin-20 targets renal cells and is associated with chronic kidney disease.
|
18639518 |
2008 |
|
Chronic kidney disease stage 5
|
0.200 |
Biomarker
|
disease |
RGD |
Interleukin-20 targets renal cells and is associated with chronic kidney disease.
|
18639518 |
2008 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis.
|
30319661 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed levels of IL-20 receptor subunit A (IL-20RA), CD55, and receptor activator of nuclear factor kappaB (NF-κB) ligand (RANKL) in RA fibroblast-like synoviocytes (FLSs) using confocal microscopy.
|
31831038 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elucidation of this interaction provides a better understanding of cytokine cross-talk in RA and a rationale for more effective biologic therapies that target IL-20R2 instead of individual cytokines from IL-20 family.
|
27619991 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients.
|
18061474 |
2008 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that IL-20's interaction with its receptors might have proinflammatory effects on chronic inflammatory diseases, particularly rheumatoid arthritis (RA), osteoporosis, and breast cancer.
|
24816455 |
2014 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory bone disorders likes intervertebral disc herniation, rheumatoid arthritis (RA), osteoporosis, and bone fracture.
|
30250404 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in inflammatory diseases such as psoriasis, atherosclerosis, and rheumatoid arthritis, etc.
|
18758357 |
2008 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA.
|
29690863 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and its receptors were detected in RA synovial fibroblasts (RASFs), using immunohistochemical staining.
|
16947773 |
2006 |