IL20, interleukin 20, 50604

N. diseases: 111; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE The association between the IL-20-1723C→G allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. 21109726 2011
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP). 17263806 2007
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE Although association analysis of the IL-19 gene indicated that minor alleles of the IL-19 gene SNPs (rs2243188, rs2243169 and rs2243158) revealed protective effect to psoriasis and haplotype analysis of the IL-19 gene proved significant protective effect of the TGATA haplotype in case of late-onset disease, combined haplotype analysis of the IL-19 and -20 genes demonstrated that protective effect of the IL-19 gene is secondary to the susceptibility effect of the IL-20 gene. 15496954 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE In our previous study, a single-nucleotide polymorphism (SNP) of IL-20-1723CG (rs1713239) was found to be associated with psoriasis progression, especially in those induced by upper respiratory tract infection. 23892591 2014
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis. 14712309 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE In the present study we tested the hypotheses that genetic variations of the IL-20-RI influence susceptibility to psoriasis and investigated single nucleotide polymorphisms (SNPs) in the IL20RA and IL20RB genes in psoriasis patients (n=254) and healthy controls (n=224). 18480827 2008
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE Nevertheless, family-based studies are required to confirm the impact of IL-19, IL-20 and IL-24 genes in the genetic predisposition for psoriasis. 15889129 2005
CUI: C0033860
Disease: Psoriasis
Psoriasis 		0.100 GeneticVariation disease BEFREE Carriers of the IL10 T allele (rs1554286) and the IL20 T allele (rs1400986) conferred protection from psoriasis [odds ratio (OR) = 0·63, corrected P-value (Pc) = 0·007; OR = 0·62, Pc = 0·038, respectively]. 28150860 2017
CUI: C0149745
Disease: Oral Ulcer
Oral Ulcer 		0.100 GeneticVariation disease GWASCAT Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci. 30837455 2019
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.030 GeneticVariation disease BEFREE Our previous studies mapped a T104M mutation in interleukin-20 receptor beta (<i>IL-20RB</i>) in a family with primary open angle glaucoma (POAG). 31205408 2019
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.030 GeneticVariation disease BEFREE A T104M mutation in IL20-R2 was identified in a large POAG family in which the GLC1C locus was originally mapped. pHDFs harboring this mutation had significantly increased phosphorylated STAT3 (pSTAT3) activity compared with normal HDFs. 24455976 2014
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.030 GeneticVariation disease BEFREE In particular, our lab recently identified a T104M mutation in IL-20 receptor-B (IL-20RB) in primary open angle glaucoma patients from a large pedigree. 26903709 2016
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.020 GeneticVariation disease BEFREE The results suggest that the GG genotypes of the IL-20 polymorphisms (rs2981573 and rs2232360) might have an important role in the development of UC in the Mexican population. 23183096 2013
CUI: C0041912
Disease: Upper Respiratory Infections
Upper Respiratory Infections 		0.020 GeneticVariation group BEFREE In our previous study, a single-nucleotide polymorphism (SNP) of IL-20-1723CG (rs1713239) was found to be associated with psoriasis progression, especially in those induced by upper respiratory tract infection. 23892591 2014
CUI: C0041912
Disease: Upper Respiratory Infections
Upper Respiratory Infections 		0.020 GeneticVariation group BEFREE The association between the IL-20-1723C→G allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population. 21109726 2011
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.020 GeneticVariation disease BEFREE The haplotype analysis revealed associations of 2 IL19/IL20 extended haplotypes (AACGTAA and ACCGTAA) and 2 IL20RB haplotypes (AGTA and AGGA) with vitiligo, remaining significant after correction for multiple testing. 20699607 2010
CUI: C1847835
Disease: VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) 		0.020 GeneticVariation disease BEFREE The haplotype analysis revealed associations of 2 IL19/IL20 extended haplotypes (AACGTAA and ACCGTAA) and 2 IL20RB haplotypes (AGTA and AGGA) with vitiligo, remaining significant after correction for multiple testing. 20699607 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 GeneticVariation disease BEFREE These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis. 18479293 2008
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 GeneticVariation disease LHGDN These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis. 18479293 2008
CUI: C0030246
Disease: Pustulosis of Palms and Soles
Pustulosis of Palms and Soles 		0.010 GeneticVariation disease BEFREE This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP). 17263806 2007
CUI: C0031106
Disease: Aggressive Periodontitis
Aggressive Periodontitis 		0.010 GeneticVariation disease BEFREE Extended haplotype analysis revealed an association of IL19/IL20 haplotype GACACCGGAA with a higher risk for PPP (OR 2 x 31, 95% CI 1 x 05-5 x 10) and of IL20/IL24 haplotype CAAAC with a reduced risk for PPP (OR 0 x 12, 95% CI 0 x 02-0 x 82). 17263806 2007
CUI: C0042580
Disease: Vesico-Ureteral Reflux
Vesico-Ureteral Reflux 		0.010 GeneticVariation disease BEFREE IL-19 and IL-20 genes polymorphisms and haplotype analysis in a vesicoureteral reflux population. 23000500 2013
CUI: C0043144
Disease: Wheezing
Wheezing 		0.010 GeneticVariation phenotype BEFREE The association of IL20 SNP rs2981573 with recurrent wheeze was confirmed in a healthy birth cohort. 21814157 2011
CUI: C0343055
Disease: Generalized pustular psoriasis
Generalized pustular psoriasis 		0.010 GeneticVariation disease BEFREE This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP). 17263806 2007
CUI: C0375023
Disease: Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site 		0.010 GeneticVariation disease BEFREE Haplotype analysis of the combined IL19/IL20 genotyped polymorphisms demonstrated an inverse association between the TGG haplotype and recurrent wheeze after RSV LRTI. 21814157 2011