|
Diabetes Mellitus, Insulin-Dependent
|
0.310 |
Biomarker
|
disease |
BEFREE |
Conversely, both IL-20 and transforming growth factor (TGF-β) decreased in T1D-EV<sup>+</sup> versus EV<sup>-</sup> , while IL-4, -6 and -13 did not show any changes.
|
28640379 |
2017 |
|
Kidney Failure, Acute
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We analyzed the expression of IL-20 and its receptor (R) in the kidneys of rats with HgCl(2)-induced acute renal failure.
|
18496552 |
2008 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
Our study established increased risk for MDD related to the IL20 and IL24 haplotype and suggests that cytokines may contribute to the pathogenesis of MDD.
|
19087313 |
2008 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis.
|
30319661 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed levels of IL-20 receptor subunit A (IL-20RA), CD55, and receptor activator of nuclear factor kappaB (NF-κB) ligand (RANKL) in RA fibroblast-like synoviocytes (FLSs) using confocal microscopy.
|
31831038 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elucidation of this interaction provides a better understanding of cytokine cross-talk in RA and a rationale for more effective biologic therapies that target IL-20R2 instead of individual cytokines from IL-20 family.
|
27619991 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that IL-20's interaction with its receptors might have proinflammatory effects on chronic inflammatory diseases, particularly rheumatoid arthritis (RA), osteoporosis, and breast cancer.
|
24816455 |
2014 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory bone disorders likes intervertebral disc herniation, rheumatoid arthritis (RA), osteoporosis, and bone fracture.
|
30250404 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in inflammatory diseases such as psoriasis, atherosclerosis, and rheumatoid arthritis, etc.
|
18758357 |
2008 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA.
|
29690863 |
2018 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and its receptors were detected in RA synovial fibroblasts (RASFs), using immunohistochemical staining.
|
16947773 |
2006 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and IL-22 mRNA levels were also upregulated in RA SFMCs but their level of expression was lower than that of IL-10 or IL-19.
|
20001767 |
2010 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
|
24437572 |
2014 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on current knowledge of IL-20's involvement in the pathogenesis of rheumatoid arthritis.
|
26297177 |
2017 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-20 in RA synovial tissue was particularly associated with macrophages and neutrophil granulocytes, but also with synovial fibroblasts and lymphocytes.
|
28662439 |
2017 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20, an IL-10 family member, is involved in various inflammatory diseases, such as psoriasis, rheumatoid arthritis, and atherosclerosis.
|
19342680 |
2009 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure.
|
29999545 |
2018 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study suggests that different cytokines are players in the psoriasis pathogenesis although only the IL-10 family members IL-22 and IL-20 directly cause the characteristic epidermal alterations.
|
19330474 |
2009 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
During treatment with calcipotriol or CsA, IL-19 and IL-20 mRNA levels decrease in accordance with the clinical improvement of psoriasis.
|
16225599 |
2005 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between the IL-20-1723C→G allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population.
|
21109726 |
2011 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP).
|
17263806 |
2007 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is a proinflammatory cytokine of the IL-10 family that is involved in psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.
|
21844205 |
2011 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes.
|
19731362 |
2009 |