|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these results demonstrate a role in epidermal function and psoriasis for IL-20, a novel cytokine identified solely by bioinformatics analysis.
|
11163236 |
2001 |
|
Skin Abnormalities
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Overexpression of IL-20 in transgenic (TG) mice causes neonatal lethality with skin abnormalities including aberrant epidermal differentiation.
|
11163236 |
2001 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It remains to be clarified whether IL-19 and IL-20 are implicated in the pathogenesis of psoriasis.
|
14675174 |
2003 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the interleukin-20 gene: relationships to plaque-type psoriasis.
|
14712309 |
2004 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although association analysis of the IL-19 gene indicated that minor alleles of the IL-19 gene SNPs (rs2243188, rs2243169 and rs2243158) revealed protective effect to psoriasis and haplotype analysis of the IL-19 gene proved significant protective effect of the TGATA haplotype in case of late-onset disease, combined haplotype analysis of the IL-19 and -20 genes demonstrated that protective effect of the IL-19 gene is secondary to the susceptibility effect of the IL-20 gene.
|
15496954 |
2004 |
|
Hepatitis C
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that variants of the immunomodulatory IL10 and IL19/IL20 genes may be involved in natural clearance of HCV in the African-American population.
|
15815689 |
2005 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In sum, we show that Ad-mda7 is able to induce growth inhibition and apoptosis in pancreatic cancer cells via inhibition of the Wnt/PI3K pathways and identify a novel bystander mechanism of MDA-7 killing in pancreatic cancer that functions via IL-20 receptors.
|
15851011 |
2005 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
In sum, we show that Ad-mda7 is able to induce growth inhibition and apoptosis in pancreatic cancer cells via inhibition of the Wnt/PI3K pathways and identify a novel bystander mechanism of MDA-7 killing in pancreatic cancer that functions via IL-20 receptors.
|
15851011 |
2005 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nevertheless, family-based studies are required to confirm the impact of IL-19, IL-20 and IL-24 genes in the genetic predisposition for psoriasis.
|
15889129 |
2005 |
|
Psoriasis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
During treatment with calcipotriol or CsA, IL-19 and IL-20 mRNA levels decrease in accordance with the clinical improvement of psoriasis.
|
16225599 |
2005 |
|
Skin lesion
|
0.020 |
AlteredExpression
|
group |
BEFREE |
To study the dynamics of IL-19 and IL-20 gene expression as well as the expression of their receptor subunits in psoriatic skin lesions.
|
16225599 |
2005 |
|
Tumor Angiogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In vivo, IL-20 also enhanced tumor angiogenesis.
|
16511554 |
2006 |
|
Psoriasis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these data indicate that IL-20 may be an important effector cytokine in psoriasis, and that its inhibition may represent a potential therapeutic target.
|
16645593 |
2006 |
|
Inflammation
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
Hence, IL-20 may influence inflammation through IFN-like effects.
|
16645593 |
2006 |
|
Epithelial hyperplasia of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
We assessed expression of IL-20 and its receptors in psoriasis, given the recent implication of IL-20 in epidermal hyperplasia.
|
16645593 |
2006 |
|
Dermatologic disorders
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Stimulation of IL-20 expression in keratinocytes by UVB light suggests that this cytokine might participate in skin responses to this ever-present environmental factor and potentially has a role in UV light-associated dermatoses.
|
16709143 |
2007 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
LHGDN |
Therefore, we sought to investigate whether IL-20 is associated with atherosclerosis.
|
16778121 |
2006 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and its receptors were detected in RA synovial fibroblasts (RASFs), using immunohistochemical staining.
|
16947773 |
2006 |
|
Arthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Thus, IL-20 may modulate the incidence and severity of arthritis and play important roles at local sites of inflammation.
|
16947773 |
2006 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP).
|
17263806 |
2007 |
|
Pustulosis of Palms and Soles
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP).
|
17263806 |
2007 |
|
Aggressive Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Extended haplotype analysis revealed an association of IL19/IL20 haplotype GACACCGGAA with a higher risk for PPP (OR 2 x 31, 95% CI 1 x 05-5 x 10) and of IL20/IL24 haplotype CAAAC with a reduced risk for PPP (OR 0 x 12, 95% CI 0 x 02-0 x 82).
|
17263806 |
2007 |
|
Generalized pustular psoriasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether variations in the IL19, IL20 and IL24 genes that have previously been associated with plaque-type psoriasis may also play a role in palmoplantar pustulosis (PPP).
|
17263806 |
2007 |
|
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients.
|
18061474 |
2008 |
|
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis.
|
18479293 |
2008 |