GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 AlteredExpression disease BEFREE Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). 19287997 2009
CUI: C0023532
Disease: Leukoplakia, Oral
Leukoplakia, Oral 		0.010 AlteredExpression disease BEFREE Gal-1 protein was significantly overexpressed in OSCC cancer cells and OPL prickle cells compared to NOM (P<0.05). 19287997 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.030 AlteredExpression disease BEFREE Galanin expression is also upregulated in the experimental autoimmune encephalomyelitis (EAE) model of MS, although solely in oligodendrocytes. 19717462 2009
CUI: C3888194
Disease: MIXED LINEAGE LEUKEMIA
MIXED LINEAGE LEUKEMIA 		0.010 Biomarker disease BEFREE Gal-1 transcripts were significantly more abundant in MLL-rearranged B-ALLs. 20332322 2010
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE Gal-1 transcripts were significantly more abundant in MLL-rearranged B-ALLs. 20332322 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.010 Biomarker disease BEFREE GAL and PACAP38 were not detected in sham hearts, but peptide immunoreactivity was high in the infarct three days after MI. 21035185 2011
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.010 Biomarker disease BEFREE Galanin participates in the pathogenesis of acute pancreatitis (AP). 21303427 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 Biomarker group BEFREE Gal-1-induced IL-10(+) T cells efficiently suppressed T cell proliferation and T cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. 22345665 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 Biomarker group BEFREE Gal-1-induced IL-10(+) T cells efficiently suppressed T cell proliferation and T cell-mediated inflammation and promoted the establishment of cancer immune-privileged sites. 22345665 2012
CUI: C0003467
Disease: Anxiety
Anxiety 		0.090 Biomarker disease BEFREE Galanin (GAL) and neuropeptide Y (NPY) are neuropeptides involved in behaviors associated with anxiety. 24841617 2015
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		0.090 Biomarker group BEFREE Galanin (GAL) and neuropeptide Y (NPY) are neuropeptides involved in behaviors associated with anxiety. 24841617 2015
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.070 AlteredExpression group BEFREE GAL1 has been found to be upregulated in many malignancies; yet the role of GAL1 in the pathophysiology of human osteosarcoma (OS) remains uncertain. 25069486 2014
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		0.020 Biomarker disease BEFREE GAL1 has been found to be upregulated in many malignancies; yet the role of GAL1 in the pathophysiology of human osteosarcoma (OS) remains uncertain. 25069486 2014
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		0.020 Biomarker disease BEFREE GAL1 has been found to be upregulated in many malignancies; yet the role of GAL1 in the pathophysiology of human osteosarcoma (OS) remains uncertain. 25069486 2014
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		0.020 Biomarker disease BEFREE GAL1 has been found to be upregulated in many malignancies; yet the role of GAL1 in the pathophysiology of human osteosarcoma (OS) remains uncertain. 25069486 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.060 Biomarker group BEFREE Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. 25504183 2015
CUI: C0677948
Disease: Stage II Colorectal Cancer
Stage II Colorectal Cancer 		0.010 Biomarker disease BEFREE Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. 25504183 2015
CUI: C3146252
Disease: Stage II Colorectal Cancer AJCC v7
Stage II Colorectal Cancer AJCC v7 		0.010 Biomarker disease BEFREE Galanin plays an important role in cancer invasiveness and is associated with poor prognosis in stage II colorectal cancer. 25504183 2015
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET GAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests. 25522404 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET GAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests. 25522404 2014
CUI: C0041182
Disease: Trophoblastic Neoplasms
Trophoblastic Neoplasms 		0.010 Biomarker group BEFREE Gal-1 silenced trophoblast tumor cells (BeWo) show decreased syncytium formation and different miRNA production compared to non-target silenced BeWo cells. 26418280 2016
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Gal-1 is associated with tumor progression, and is a potent immune suppressor in the tumor micro-environment. 26902800 2016
CUI: C3203533
Disease: Psychological Trauma
Psychological Trauma 		0.010 Biomarker disease BEFREE Galanin and its agonists may be used to develop a novel preventive and therapeutic strategy to prevent and treat exercise-induced somatic and psychological trauma. 27548997 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.040 AlteredExpression phenotype BEFREE Gal-1-mediated activation of a disintegrin and metalloproteinase 10 (ADAM10) and ADAM 17 increased the invasion activity and expression of mesenchymal characteristics in LPS-activated CRC cells. 27837433 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Gal-1 expression and T cell apoptosis were evaluated in 6 high-power fields (3 in the tumour and 3 in the stroma). 28108653 2017