GAL, galanin and GMAP prepropeptide, 51083

N. diseases: 226; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease BEFREE Correcting abnormal galanin function in depression could prove to be a novel target for drug development. 24706871 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET In recent years, numerous studies of animal models have suggested an involvement of GAL and GAL1 and GAL2 receptors in anxiety- and depression-related behavior. 24782539 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET GAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests. 25522404 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Correcting abnormal galanin function in depression could prove to be a novel target for drug development. 24706871 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET Correcting abnormal galanin function in depression could prove to be a novel target for drug development. 24706871 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET GAL(1-15) induced strong depression-like and anxiogenic-like effects in all the tests. 25522404 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET In recent years, numerous studies of animal models have suggested an involvement of GAL and GAL1 and GAL2 receptors in anxiety- and depression-related behavior. 24782539 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET There is a large body of pre-clinical and some clinical data to link the neuropeptide galanin to a range of physiological and pathological functions that include metabolism, depression, and addiction. 25228436 2014
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease PSYGENET These results demonstrate the beneficial effects of exercise in a rodent model of epilepsy and depression comorbidity and suggest a potential role for galanin. 23933912 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients. 23741354 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 GeneticVariation disease BEFREE The findings clearly indicate that the GAL gene polymorphism is closely correlated to the incidence of depression in the Chinese Han female patients. 23741354 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease PSYGENET These results demonstrate the beneficial effects of exercise in a rodent model of epilepsy and depression comorbidity and suggest a potential role for galanin. 23933912 2013
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease BEFREE The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment. 20237460 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment. 20237460 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease BEFREE Intracerebroventricular injection of galanin has been shown to modulate depression and anxiety-like behaviors in the rat. 18554714 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Intracerebroventricular injection of galanin has been shown to modulate depression and anxiety-like behaviors in the rat. 18554714 2008
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 AlteredExpression disease BEFREE The neuropeptide galanin is widely expressed in the periphery and the central nervous system and mediates diverse physiological processes and behaviors including alcohol abuse, depression and anxiety. 17083333 2007
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 AlteredExpression disease BEFREE The neuropeptide galanin is widely expressed in the periphery and the central nervous system and mediates diverse physiological processes and behaviors including alcohol abuse, depression and anxiety. 17083333 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease BEFREE Both pharmacological and genetic studies suggest a role for galanin in depression-like behaviour in rodent models. 16863269 2006
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker disease BEFREE Both pharmacological and genetic studies suggest a role for galanin in depression-like behaviour in rodent models. 16863269 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 AlteredExpression disease BEFREE Thus, GAL and its receptor GALR3 are differentially methylated and expressed in brains of MDD subjects in a region- and sex-specific manner. 27940914 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease CTD_human Thus, GAL and its receptor GALR3 are differentially methylated and expressed in brains of MDD subjects in a region- and sex-specific manner. 27940914 2016
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease BEFREE Association of galanin and major depressive disorder in the Chinese Han population. 23741354 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 GeneticVariation disease BEFREE Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51). 21042317 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.340 Biomarker disease BEFREE The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment. 20237460 2010