|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We genotyped 201 patients and 1023 healthy controls for risk variants in NOD2, IRGM, IL23R, ATG16L1 (CD), BTNL2 (sarcoidosis), and FLG (atopy).
|
27306066 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Unconventional autophagy mediated by the WD40 domain of ATG16L1 is derailed by the T300A Crohn disease risk polymorphism.
|
27541200 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.
|
27273576 |
2016 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)).
|
25731871 |
2016 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
ATG16L1, a protein essential for early stages of autophagy, has been implicated in the pathogenesis of Crohn's disease.
|
25767270 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
IRGM, NOD2, and ATG16L1, all of which are Crohn's disease risk factors, form a molecular complex to modulate autophagic responses to microbial products.
|
25891078 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the genetic polymorphisms of the autophagy-associated genes autophagy-related 16-like 1 (ATG16L1), immunity-related GTPase M (IRGM), Unc-51-like kinase 1 (ULK1), and NOD2 with respect to early-onset Crohn disease (CD) among Korean children.
|
25944217 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
ATG16L1 and IL23R variants and genetic susceptibility to crohn's disease: mode of inheritance based on meta-analysis of genetic association studies.
|
25738374 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The ATG16L1-T300A allele impairs clearance of pathosymbionts in the inflamed ileal mucosa of Crohn's disease patients.
|
25253126 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this review, we focus on the importance of ATG16L1 and its genetic variant (T300A) within the elementary biological processes linked to Crohn disease.
|
25906181 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism ATG16L1 T300A, associated with increased risk of Crohn's disease, impairs pathogen defense mechanisms including selective autophagy, but specific pathway interactions altered by the risk allele remain unknown.
|
26095365 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The presence of Crohn's-associated variants of NOD2 and ATG16L genes appears to be associated not only with alterations of mucosal barrier functions, and bacterial killing, but the gut microbiota, as well, reflecting a potential relationship between the host's genotype and intestinal dysbiosis, involved in disease etiology.
|
26616659 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.
|
26192919 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data suggest a novel mechanism by which the ATG16L1 CD-associated gene variant may predispose people to develop intestinal inflammation.
|
26226011 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest ADA response in CD patients is genetically predisposed by SNPs in CD risk genes and suggest ATG16L1 as most promising candidate gene for drug response in ADA treatment.
|
25712183 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
MAP, rs2241880 (ATG16L1) and rs10045431 (IL12B) were found to be significantly associated with CD.
|
24522266 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that caspase 3 activation in the presence of a common risk allele leads to accelerated degradation of ATG16L1, placing cellular stress, apoptotic stimuli and impaired autophagy in a unified pathway that predisposes to Crohn's disease.
|
24553140 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An alteration in ATG16L1 stability in Crohn disease.
|
25136803 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, variants of ATG16L1 (WT: 2.03 ± 0.19 vs homozygoot variant: 4.38 ± 0.37, P < 0.009) as well as NOD2 (C-ins) (heterozygous variant: 42.08 ± 2.94 vs homozygous variant: 75.58 ± 4.34 (P = 0.05) are associated with the phagocytic activity in patients with CD.
|
24627602 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant genotypes, affecting the efficacy of anti-tumour necrosis factor (TNF) therapies.
|
23376290 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association of IL23R and ATG16L1 with susceptibility of Crohn's disease in Chinese population.
|
25048429 |
2014 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We investigated the role of the microRNAs (miRs) MIR106B and MIR93 in induction of autophagy and bacterial clearance in human cell lines and the correlation between MIR106B and autophagy-related gene 16L1 (ATG16L1) expression in tissues from patients with CD.
|
24036151 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genomic variation of ATG16L1 (rs2241880" genes_norm="55054">T300A, rs2241880) was determined in DNA from 78 patients with CD and 12 healthy controls.
|
23964099 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study reveals MIR142-3p as a new autophagy-regulating small molecule by targeting ATG16L1, implying a role of this miRNA in intestinal inflammation and CD.
|
24401604 |
2014 |