SRF, serum response factor, 6722

N. diseases: 147; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0086692
Disease: Benign Neoplasm
Benign Neoplasm 		0.300 Therapeutic group CTD_human Cellular toxicity induced by SRF-mediated transcriptional squelching. 17116645 2007
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.300 Biomarker group CTD_human Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency. 15308739 2004
CUI: C4505456
Disease: HIV Coinfection
HIV Coinfection 		0.300 Biomarker disease CTD_human Host cell gene expression during human immunodeficiency virus type 1 latency and reactivation and effects of targeting genes that are differentially expressed in viral latency. 15308739 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE There is mounting evidence that MRTFs and SRF represent promising targets for hepatocellular carcinoma (HCC) growth. 31844251 2020
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE The identification of SRF/MCM7 complex as a target of ATO provides new insights into ATO's mechanism, which may benefit the appropriate use of this agent in the treatment of HCC. 31186405 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE Depletion of myoferlin in tumour cells from SRF-VP16-derived murine HCCs induced a senescence phenotype. 28114277 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE SRF-VP16iHep mHCC reveal convergent Ras/MAPK and Rho/actin signaling as a highly oncogenic driver mechanism for hepatocarcinogenesis. 25266280 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Expression of SRF and Snail were detected in 37.6% (55 of 146 cases) and in 12.3% (18 of 146 cases) of the HCCs, respectively. 24173109 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE High SRF expressing HCC tissues showed higher levels of expression of MMP-2 and MMP-9, compared with low SRF expressing HCC tissues. 21842128 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE In the HCC cell lines examined, siSRF797 reduced both the mRNA and protein levels of SRF without inducing unspecific interferon response or cytotoxicity. 20144681 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE The role of serum response factor in hepatocellular carcinoma: implications for disease progression. 20811705 2010
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Co-labeling studies demonstrated exclusive localization of miR-122 in the benign livers, whereas SRF predominantly expressed in HCC. 19726678 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease RGD SRF may play an important role in the development of hepatocellular carcinoma in LEC rats by mediating the proto-oncogene c-fos induction. 9570363 1997
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.220 Biomarker group BEFREE Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset. 30762586 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 Biomarker group BEFREE These data validated that SRF responded to hypoxia, which subsequently was involved in pulmonary hypertension by abnormally promoting viability of PASMCs via modulating expression of Bcl-2.. 28176371 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 Biomarker group BEFREE We here hypothesized that Rho kinase (ROCK) acts as a novel mediator that regulates intrinsic VSMC mechanical properties through the serum response factor (SRF) /myocardin pathway and consequently regulates aortic stiffness and blood pressure in hypertension. 29169155 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.220 Biomarker group RGD Increased myosin light chain kinase expression in hypertension: Regulation by serum response factor via an insertion mutation in the promoter. 16822834 2006
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.220 Biomarker group BEFREE Temporally controlled onset of dilated cardiomyopathy through disruption of the SRF gene in adult heart. 16260633 2005
CUI: C0007193
Disease: Cardiomyopathy, Dilated
Cardiomyopathy, Dilated 		0.220 Biomarker group MGD
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.200 Biomarker group RGD Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. 9570363 1997
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.200 Biomarker disease RGD Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. 9570363 1997
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.200 Biomarker disease RGD Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. 9570363 1997
CUI: C2676033
Disease: Hepatoblastoma Caused By Somatic Mutation
Hepatoblastoma Caused By Somatic Mutation 		0.200 Biomarker disease RGD Activation of serum response factor in the liver of Long-Evans Cinnamon (LEC) rat. 9570363 1997
CUI: C0023462
Disease: Acute Megakaryocytic Leukemias
Acute Megakaryocytic Leukemias 		0.100 Biomarker disease BEFREE We hypothesized that one of the SRF-regulated neuronal IEGs, activity-regulated cytoskeleton-associated protein (Arc; also termed Arg3.1), is regulated by an SRF coactivator, megakaryoblastic leukemia (MKL). 30244496 2019
CUI: C0023462
Disease: Acute Megakaryocytic Leukemias
Acute Megakaryocytic Leukemias 		0.100 Biomarker disease BEFREE Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together regulate transcription of actin cytoskeleton genes. 31582539 2019