|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
A new tumor necrosis factor (TNF)-α regulator, lipopolysaccharides-induced TNF-α factor, is associated with obesity and insulin resistance.
|
21362361 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Accordingly, TNF α has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance.
|
24139907 |
2013 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins.
|
16608891 |
2006 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, serum TNF-α levels were significantly elevated (P=0.017) and adiponectin levels reduced (total: P=0.0001; high: P=0.022) with obesity.
|
22309242 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance.
|
31659105 |
2020 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ADIPOQ, IL1 and TNF, are associated with predisposition to obesity.
|
24034586 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Aging and obesity are associated with elevated pro-inflammatory cytokines such as monocyte chemoattractant protein (MCP)-1 and tumor necrosis factor (TNF)α, which are linked to insulin resistance.
|
25450249 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, these results suggest that basolateral TNF-α, which can be produced by adipocytes and macrophages during obesity, would be able to activate TNF-α and other proinflammatory proteins expression in the small intestine and diminish intestinal sugar and amino acids transport.
|
30246472 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among suggested determinants for obesity with inflammation were Adenovirus-36, the gut microbiota, trans-fatty acids, and the four genes FTO, MC4R, TNF-α and LEPR.
|
22464010 |
2013 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As a member of the tumor necrosis factor-α-related protein family, complement-1q tumor necrosis factor-α-related protein isoform 5 (CTRP5) has been found to be associated with obesity and insulin resistance (IR).
|
31070007 |
2020 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
B cells from obese/insulin-resistant hosts also support oral osteoclastogenesis and both oral and systemic production of inflammatory cytokines, including pro-osteoclastogenic TNF-α and MIP-2, an ortholog of human IL-8.
|
24782490 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Background The objective of this study was to investigate the association of polymorphisms in four genes, tumor necrosis factor-α (TNFA), patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin (ADIPOQ) and apolipoprotein C3 (APOC3), with obesity and non-alcoholic fatty liver disease (NAFLD) in Asian Indian adolescents.
|
31216264 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because elevated levels of the free fatty acid (FFA) palmitate and TNF-α have been reported in obesity, we studied whether these agents interact to trigger CCL2 production.
|
29632147 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Biliverdin treatment reversed the higher gene expression of Cd11c, encoding an M1 macrophage marker, and Tnfa, encoding the proinflammatory cytokine tumor necrosis factor-α, in the adipose tissues of DIO mice.
|
31577826 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Blockade of tumor necrosis factor (TNF) receptor type 1-mediated TNF-alpha signaling protected Wistar rats from diet-induced obesity and insulin resistance.
|
18339717 |
2008 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
By comparing the hepatic responses to tumor necrosis factor (TNF)-alpha that occur during situations that promote liver injury (such as obesity or chronic exposure to ethanol) with those that occur after stimuli (such as partial hepatectomy) that lead to liver regeneration, it is apparent that hepatocytes are usually able to constrain noxious responses to TNF-alpha, such as the release of reactive oxygen from mitochondria.
|
10807515 |
2000 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CIDEC expression decreased in adipose tissue of subjects with obesity and negatively correlated with adipose TNF-α levels and systemic lipolysis.
|
27062372 |
2016 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Circulating TNF-α and the acylated/desacyl ghrelin ratio were increased, whereas desacyl ghrelin levels were decreased in patients with obesity and NAFLD.
|
30137403 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating and Adipose Tissue mRNA Levels of Zinc-α2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity.
|
29755407 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CONCLUSIONS The rs4918 minor variant is associated with lower TNFα and adiponectin, higher leptin levels in healthy persons, and more favorable anthropomorphic parameters of obesity in cohort 2.
|
27487851 |
2016 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correlation between omental TNF-alpha protein and plasma PAI-1 in obesity subjects.
|
17698217 |
2008 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cucurbita ficifolia extract decreased body mass and inflammation in MSG-obese mice by reducing the expression of TNF-α and IL-6; these decreases were parallel to significant reductions in protein levels.
|
27918843 |
2017 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α) levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase.
|
28430139 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dysregulation of several adipokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and adiponectin, contributes to the low-grade inflammation that is a hallmark of obesity.
|
21224869 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue.
|
11328671 |
2001 |