DLG5, discs large MAGUK scaffold protein 5, 9231

N. diseases: 36; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005890
Disease: Body Height
Body Height 		0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease. 16670524 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE A major role in adult Crohn's disease (CD) has been defined for 3 polymorphisms in the CARD15 gene, whereas variants in the SLC22A4, SLC22A5, and DLG5 genes could have a minor contribution to IBD susceptibility. 16670523 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023). 15503241 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Significant associations of both DLG5 polymorphisms with the development of CD in the Malaysian patients were observed in this study. 22118696 2011
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Specifically, the significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children. 17156146 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center. 16344053 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE We found a significant difference in association of the 113A DLG5 variant with Crohn disease in affected individuals carrying the risk-associated CARD15 alleles versus those carrying non-risk-associated CARD15 alleles. 15107852 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease. 15930978 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Our observations argue against a role of DLG5 polymorphisms in the susceptibility for inflammatory bowel disease, whereas the OCTN polymorphisms are associated with CD. 15955786 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Subgroup analysis also failed to show evidence of association between either DLG5 allele or genotype frequencies and ulcerative colitis or Crohn's disease. 16534418 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC). 16944184 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease. 16437728 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Recently, Stoll and colleagues reported a novel finding of genetic variation in the DLG5 gene that is associated with IBD (CD and UC combined). 15841097 2005
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE We assess the frequency of the CARD15 SNPs and of the R30Q mutation in DLG5 and their contribution to the development of CD in a cohort of unrelated IBD patients (151 CD, 325 ulcerative colitis (UC)) and healthy controls (236) from South-east Norway (IBSEN cohort). 16493449 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Polymorphisms 3020insC in CARD15 and SNP rs2165047 in DLG5 were associated with specific phenotypes in this pediatric-onset CD cohort. 17476680 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE DLG5 variants contribute to Crohn disease risk in a Canadian population. 16450402 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Further investigation of the observed TRD may contribute towards enlightening the role of DLG5 in physiological processes influencing transmission of chromosomes to the surviving offspring, which, in turn, may help in understanding its implication in the development of CD among men. 16446977 2006
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease LHGDN Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric onset of CD. 17451203 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease BEFREE Furthermore, we evaluated whether DLG5 variants alter gastrointestinal permeability in Crohn's disease (CD). 16494592 2006
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group BEFREE The single-nucleotide polymorphisms (SNPs) -1237T/C (rs5743836) and 2848A/G (rs352140=p.Pro545Pro) in TLR9, the main CD-associated variants within the genes for NOD2, IL23R, ATG16L1, and variants in the IBD5 locus and in the DLG5 gene were assessed in 956 patients with IBD (606 CD and 350 ulcerative colitis) and in 792 healthy controls. 19455129 2009
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group BEFREE Our observations argue against a role of DLG5 polymorphisms in the susceptibility for inflammatory bowel disease, whereas the OCTN polymorphisms are associated with CD. 15955786 2005
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group BEFREE Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases. 17451203 2007
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group BEFREE We assess the frequency of the CARD15 SNPs and of the R30Q mutation in DLG5 and their contribution to the development of CD in a cohort of unrelated IBD patients (151 CD, 325 ulcerative colitis (UC)) and healthy controls (236) from South-east Norway (IBSEN cohort). 16493449 2006
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.100 GeneticVariation group LHGDN DLG5 113A is associated with increased susceptibility to IBD in Scottish children. 17307543 2007