|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
|
24910533 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease.
|
16670524 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A major role in adult Crohn's disease (CD) has been defined for 3 polymorphisms in the CARD15 gene, whereas variants in the SLC22A4, SLC22A5, and DLG5 genes could have a minor contribution to IBD susceptibility.
|
16670523 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023).
|
15503241 |
2004 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant associations of both DLG5 polymorphisms with the development of CD in the Malaysian patients were observed in this study.
|
22118696 |
2011 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease.
|
16773680 |
2006 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study suggests that SNPs (T>C substitution) affect the function of the DLG5 protein and thus play a role in the development of IBD, in particular Crohn's disease.
|
30648106 |
2018 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
As there is substantial crosstalk between CARD-mediated pathways, both CD susceptibility genes, NOD2 and DLG5, may interact functionally to contribute to CD risk.
|
18335190 |
2008 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility.
|
19455129 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specifically, the significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children.
|
17156146 |
2007 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.
|
16437728 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center.
|
16344053 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation of the observed TRD may contribute towards enlightening the role of DLG5 in physiological processes influencing transmission of chromosomes to the surviving offspring, which, in turn, may help in understanding its implication in the development of CD among men.
|
16446977 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found a significant difference in association of the 113A DLG5 variant with Crohn disease in affected individuals carrying the risk-associated CARD15 alleles versus those carrying non-risk-associated CARD15 alleles.
|
15107852 |
2004 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease.
|
15930978 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variants in CARD15, TLR4, NOD1, CARD8, and DLG5 associated with CD were tested as well.
|
17206668 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our observations argue against a role of DLG5 polymorphisms in the susceptibility for inflammatory bowel disease, whereas the OCTN polymorphisms are associated with CD.
|
15955786 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease.
|
16773680 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis also failed to show evidence of association between either DLG5 allele or genotype frequencies and ulcerative colitis or Crohn's disease.
|
16534418 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have now examined the association of the R30Q polymorphism in a large cohort of British IBD cases, tested for interaction between the DLG5 and CARD15 genes and assessed possible association of DLG5 with clinical features of Crohn's disease (CD) and ulcerative colitis (UC).
|
16944184 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.
|
16437728 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric onset of CD.
|
17451203 |
2007 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, Stoll and colleagues reported a novel finding of genetic variation in the DLG5 gene that is associated with IBD (CD and UC combined).
|
15841097 |
2005 |