|
Alanine aminotransferase measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
|
29403010 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Like RAB6KIFL, DLG5 was overexpressed in PDACs, and knockdown of endogenous DLG5 by small interfering RNA significantly suppressed the growth of PDAC cells as well.
|
15665285 |
2005 |
|
Bladder Neoplasm
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These data suggest that inhibition of Dlg5 by DNA hypermethylation contributes to provoke invasive phenotypes in bladder tumor.
|
25478998 |
2015 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In summary, loss of DLG5 expression promoted breast cancer malignancy by inactivating the Hippo signaling pathway and increasing nuclear YAP.
|
28169360 |
2017 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data indicate that down-regulated DLG5 expression increases the stemness of breast cancer cells by enhancing TAZ expression, contributing to TAM resistance in breast cancer.
|
30450766 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results imply that collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic carcinogenesis.
|
15665285 |
2005 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of clinical significance, Kaplan-Meier analysis showed that downregulation of Dlg5 is significantly associated with reduced overall survival in patients with bladder cancer.
|
25478998 |
2015 |
|
Celiac Disease
|
0.020 |
Biomarker
|
disease |
LHGDN |
Association of DLG5 variants with gluten-sensitive enteropathy.
|
18559397 |
2008 |
|
Celiac Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our study does not support the effect of the R30Q DLG5 variant in CeD or IBD predisposition in the Spanish population.
|
20796250 |
2011 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
|
24910533 |
2014 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease.
|
16670524 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A major role in adult Crohn's disease (CD) has been defined for 3 polymorphisms in the CARD15 gene, whereas variants in the SLC22A4, SLC22A5, and DLG5 genes could have a minor contribution to IBD susceptibility.
|
16670523 |
2006 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023).
|
15503241 |
2004 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Significant associations of both DLG5 polymorphisms with the development of CD in the Malaysian patients were observed in this study.
|
22118696 |
2011 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The initial report of DLG5 as a novel IBD susceptibility gene sparked a multitude of studies investigating its effect on CD and IBD, respectively, leading to controversial findings and ongoing discussions concerning the validity of the initial association finding and its role in the aetiology of Crohn disease.
|
16773680 |
2006 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study suggests that SNPs (T>C substitution) affect the function of the DLG5 protein and thus play a role in the development of IBD, in particular Crohn's disease.
|
30648106 |
2018 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
As there is substantial crosstalk between CARD-mediated pathways, both CD susceptibility genes, NOD2 and DLG5, may interact functionally to contribute to CD risk.
|
18335190 |
2008 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide evidence for genetic interactions between polymorphisms in TLR9 and CD-associated variants in NOD2, IL23R, and DLG5, differentially modulating CD susceptibility.
|
19455129 |
2009 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specifically, the significant negative association found between DLG5 R30Q and CD in female children suggests DLG5 may have a protective effect in CD susceptibility for female children.
|
17156146 |
2007 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.
|
16437728 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
|
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center.
|
16344053 |
2005 |
|
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation of the observed TRD may contribute towards enlightening the role of DLG5 in physiological processes influencing transmission of chromosomes to the surviving offspring, which, in turn, may help in understanding its implication in the development of CD among men.
|
16446977 |
2006 |