Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We validated these candidate genes in Japanese patients with CD and found a weak but possible association with both SLC22A4 (P=0.028) and DLG5 (P=0.023).
|
15503241 |
2004 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found a significant difference in association of the 113A DLG5 variant with Crohn disease in affected individuals carrying the risk-associated CARD15 alleles versus those carrying non-risk-associated CARD15 alleles.
|
15107852 |
2004 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We refined our previously defined linkage region for IBD on chromosome 10q23 and used positional cloning to identify genetic variants in DLG5 associated with IBD.
|
15107852 |
2004 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
LHGDN |
We refined our previously defined linkage region for IBD on chromosome 10q23 and used positional cloning to identify genetic variants in DLG5 associated with IBD.
|
15107852 |
2004 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.
|
16437728 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center.
|
16344053 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease.
|
15930978 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our observations argue against a role of DLG5 polymorphisms in the susceptibility for inflammatory bowel disease, whereas the OCTN polymorphisms are associated with CD.
|
15955786 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease.
|
16437728 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, Stoll and colleagues reported a novel finding of genetic variation in the DLG5 gene that is associated with IBD (CD and UC combined).
|
15841097 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our observations argue against a role of DLG5 polymorphisms in the susceptibility for inflammatory bowel disease, whereas the OCTN polymorphisms are associated with CD.
|
15955786 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This study provides support for the hypothesis that DLG5 constitutes a true IBD risk factor of modest effect.
|
15841097 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
On analysis of the DLG5 variant 113A, there were no associations with IBD when allelic frequency (11.4% IBD v 13.2% HC; p = 0.30) and carrier frequency (19.2% IBD v 24.6% HC; p = 0.069) were analysed.
|
15843420 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
LHGDN |
The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease.
|
15930978 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center.
|
16344053 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
This study provides support for the hypothesis that DLG5 constitutes a true IBD risk factor of modest effect.
|
15841097 |
2005 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The article discusses current information on the relation between CARD15 variants and Crohn disease and the discoveries of SLC22A4/SLC22A5 and DLG5 gene variants that also confer risk for inflammatory bowel disease.
|
15930978 |
2005 |
Ulcerative Colitis
|
0.080 |
Biomarker
|
disease |
BEFREE |
DLG5 and OCTN do not play a role in the susceptibility to IBD, CD, or ulcerative colitis in the Flemish population but play a role in the phenotypic expression of the disease.
|
16344053 |
2005 |
Ulcerative Colitis
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Recently, Stoll and colleagues reported a novel finding of genetic variation in the DLG5 gene that is associated with IBD (CD and UC combined).
|
15841097 |
2005 |
Ulcerative Colitis
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
No significant association of DLG5 polymorphisms with CD or UC was observed.
|
15955786 |
2005 |
Ulcerative Colitis
|
0.080 |
Biomarker
|
disease |
BEFREE |
No associations between DLG5 and UC were observed.
|
15843420 |
2005 |
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
LHGDN |
Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.
|
15665285 |
2005 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results imply that collaboration of RAB6KIFL and DLG5 is likely to be involved in pancreatic carcinogenesis.
|
15665285 |
2005 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Like RAB6KIFL, DLG5 was overexpressed in PDACs, and knockdown of endogenous DLG5 by small interfering RNA significantly suppressed the growth of PDAC cells as well.
|
15665285 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease.
|
16670524 |
2006 |