Ulcerative Colitis
|
0.080 |
Biomarker
|
disease |
BEFREE |
DLG5 and OCTN do not play a role in the susceptibility to IBD, CD, or ulcerative colitis in the Flemish population but play a role in the phenotypic expression of the disease.
|
16344053 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DLG5 variants contribute to Crohn disease risk in a Canadian population.
|
16450402 |
2006 |
Irritable Bowel Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease.
|
16670524 |
2006 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease.
|
16670524 |
2006 |
Pediatric Crohn's disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
DLG5 R30Q variant is a female-specific protective factor in pediatric onset Crohn's disease.
|
17156146 |
2007 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
LHGDN |
DLG5 113A is associated with increased susceptibility to IBD in Scottish children.
|
17307543 |
2007 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
DLG5 113A is associated with increased susceptibility to IBD in Scottish children.
|
17307543 |
2007 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
LHGDN |
DLG5 30Q is associated with a small reduction in risk of CD in women.
|
17693570 |
2008 |
Inflammatory Bowel Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Discs large homolog 5 (DLG5), a member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, has been associated with Crohn's disease (CD), but its role in the pathogenesis of this inflammatory bowel disease is disputed.
|
18335190 |
2008 |
Familial (FPAH)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
DLG5 rs1248696" genes_norm="9231">R30Q (rs1248696) and G1066G (rs1248634) were analyzed with PCR-based RFLP methods in a total of 521 subjects, that included 105 individuals with IBD and 139 without IBD from a familial IBD registry, 107 with sporadic IBD, and 170 unrelated healthy controls.
|
20037206 |
2009 |
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Dlg5 has been reported to participate in cancer progression; however, its role in prostate cancer still remains poorly understood.
|
24662825 |
2015 |
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
DLG5 in cell polarity maintenance and cancer development.
|
24910533 |
2014 |
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
DLG5 in cell polarity maintenance and cancer development.
|
24910533 |
2014 |
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Dlg5 (Discs large homolog 5), a member of the membrane-associated guanylate kinase adaptor family of scaffolding proteins, has been shown to participate in cancer progression.
|
25478998 |
2015 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center.
|
16344053 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A cohort of 2032 individuals was genotyped for disease-associated OCTN and DLG5 variants, including 981 patients with IBD (CD, n = 769; ulcerative colitis, n = 186; indeterminate colitis, n = 26) followed up at a tertiary IBD center.
|
16344053 |
2005 |
Crohn Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A major role in adult Crohn's disease (CD) has been defined for 3 polymorphisms in the CARD15 gene, whereas variants in the SLC22A4, SLC22A5, and DLG5 genes could have a minor contribution to IBD susceptibility.
|
16670523 |
2006 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A major role in adult Crohn's disease (CD) has been defined for 3 polymorphisms in the CARD15 gene, whereas variants in the SLC22A4, SLC22A5, and DLG5 genes could have a minor contribution to IBD susceptibility.
|
16670523 |
2006 |
Inflammatory Bowel Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A significant association between the DLG5 variant (R30Q) and inflammatory bowel disease (IBD) has been confirmed in several independent adult IBD cohorts.
|
17156146 |
2007 |
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
As the CARD15 risk alleles had previously been assessed in our collection of 496 MS trios, we focused our efforts on the DLG5 risk allele and the IBD5(risk) haplotype (IBD5(risk)) for MS.
|
16642031 |
2006 |
Multiple Chronic Conditions
|
0.010 |
Biomarker
|
disease |
BEFREE |
As the other family members, DLG5 contains the multi-PDZ, SH3 and GUK domains.
|
24910533 |
2014 |
Crohn Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
As there is substantial crosstalk between CARD-mediated pathways, both CD susceptibility genes, NOD2 and DLG5, may interact functionally to contribute to CD risk.
|
18335190 |
2008 |
Celiac Disease
|
0.020 |
Biomarker
|
disease |
LHGDN |
Association of DLG5 variants with gluten-sensitive enteropathy.
|
18559397 |
2008 |
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Both Girdin and Tks5, but not the Tks5 nonphosphorylatable mutant, were responsible for the enhanced invadopodium formation and invasion of Dlg5-silenced HepG2 cells.
|
28390157 |
2017 |