|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
rEL is expressed in multiple tissues and may have many physiological and pathophysiological functions, such as in the regulation of cholesterol metabolism and atherosclerosis.
|
22240910 |
2012 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased hepatic expression of EL attenuates cholesterol diet-induced hypercholesterolemia and protects against atherosclerosis.
|
28546217 |
2017 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
More mechanistic insights into the diverse biological properties of these enzymes are therefore required to firmly establish EL and HL as targets for the treatment of atherosclerotic cardiovascular disease.
|
21424685 |
2011 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The available data regarding the impact of EL expression and activity on HDL metabolism, reverse cholesterol transport, and atherosclerosis are reviewed.
|
20962428 |
2010 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, in atherosclerosis prone LDLR(-/-)ApoB(100/100) mice, systemic adenoviral gene transfer with human VEGF-A decreased EL mRNA in peripheral tissues and increased plasma HDL cholesterol.
|
23102786 |
2012 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To investigate the effects of inflammatory factor interleukin (IL)‑6 on the expression of endothelial lipase (EL) and its potential signaling pathways in atherosclerosis, a primary culture of human umbilical vein endothelial cells (HUVECs) was established and treated as follows: i) Control group without any treatment; ii) recombinant human (rh)IL‑6 treatment (10 ng/ml) for 0, 4, 8, 12 and 24 h; iii) p38 mitogen‑activated protein kinases (MAPKs) inhibitor (SB203580, 10 µmol/l) pretreatment for 1 h prior to rhIL‑6 (10 ng/ml) treatment; iv) nuclear factor (NF)‑κB activation inhibitor (pyrrolidine dithiocarbamate, 10 mmol/l) pretreatment for 1 h prior to rhIL‑6 (10 ng/ml) treatment.
|
27430252 |
2016 |
|
Autistic Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Individual common variants exert weak effects on the risk for autism spectrum disorders.
|
22843504 |
2012 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations.
|
19411665 |
2009 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population.
|
17986713 |
2008 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population.
|
24634127 |
2014 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The endothelial lipase gene (584 C/T) T allele might be protective in association with coronary artery disease.
|
30150432 |
2018 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The associations between endothelial lipase 584C/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis.
|
24886585 |
2014 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population.
|
27612170 |
2016 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers of LIPG mutations exhibited trends toward reduced coronary artery disease in 4 independent cohorts (meta-analysis odds ratio, 0.7; P=0.04).
|
23243195 |
2013 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of 584C/T polymorphism in endothelial lipase gene with risk of coronary artery disease.
|
31020688 |
2019 |
|
Coronary Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The full and total EL mass were measured in 556 patients with coronary artery disease.
|
31473149 |
2019 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Endothelial lipase genetic polymorphisms and the lipid-lowering response in patients with coronary artery disease on rosuvastatin.
|
27600285 |
2016 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of endothelial lipase gene-384A/C with coronary artery disease in Han Chinese people.
|
26124511 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of endothelial lipase gene-384A/C with coronary artery disease in Han Chinese people.
|
26124511 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations of Rs3744841 and Rs3744843 Polymorphisms in Endothelial Lipase Gene with Risk of Coronary Artery Disease and Lipid Levels in a Chinese Population.
|
27612170 |
2016 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers of LIPG mutations exhibited trends toward reduced coronary artery disease in 4 independent cohorts (meta-analysis odds ratio, 0.7; P=0.04).
|
23243195 |
2013 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Endothelial lipase genetic polymorphisms and the lipid-lowering response in patients with coronary artery disease on rosuvastatin.
|
27600285 |
2016 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between a common polymorphism of the endothelial lipase gene and early-onset coronary artery disease in a Chinese Han population.
|
24634127 |
2014 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The full and total EL mass were measured in 556 patients with coronary artery disease.
|
31473149 |
2019 |
|
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We determined the relationship between inflammatory markers and EL levels in a cohort of healthy persons recruited on the basis of family history of coronary disease.
|
18212282 |
2008 |