Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to find the putative gastric cancer predisposing gene defect in a family with HDGC that had previously been tested negative for mutations in CDH1.
|
25576241 |
2015 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer.
|
26334097 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer.
|
26072394 |
2015 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
TP53 mutation, allelic deletion of the APC gene and nuclear staining of β-catenin are frequently detected in the intestinal phenotype of GC, whereas CDH1 gene mutation, microsatellite instability and DNA hypermethylation of MLH1 are common events in the gastric phenotype of GC.
|
26033320 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Carriers of CDH1 mutations are at risk for a highly penetrant, aggressive and early-onset diffuse-type gastric cancer, and these individuals are usually offered prophylactic total gastrectomy.
|
26363540 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Greater CDH1 1054del83 transcripts were observed in gastric cancer (GC) cell lines than human gastric mucosal epithelial cell line GES-1.
|
26674321 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis failed to confirm the association between the CDH1 C-160A polymorphism and risk of gastric cancer.
|
25599647 |
2015 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, we systematically reviewed the studies of CDH1 hypermethylation and GC, and evaluated the association between CDH1 hypermethylation and GC using meta-analysis methods.
|
25926721 |
2015 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, the involvement of DNMT3A in promoting GC cell migration was associated with the promoter methylation-mediated repression of CDH1.
|
25874772 |
2015 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354).
|
26136075 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%).
|
25882375 |
2015 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Probands from two Danish families with gastric cancer and a history suggesting HDGC were screened for CDH1 gene mutations.
|
24389957 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study evaluated the effect of PTG on health-related quality of life (HRQL) in asymptomatic individuals with identified CDH1 mutations at high risk for gastric cancer.
|
24424140 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the first Korean case of presymptomatic detection of CDH1 mutation, and it highlights the importance of genetic screening for individuals with a family history of GC, especially in high-risk geographical areas.
|
25187893 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene.
|
23812922 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Germline inactivation of the E-cadherin gene (CDH1) is associated with hereditary diffuse gastric cancer (HDGC), a rare autosomal dominant syndrome predisposing to both diffuse gastric cancer (DGC) and lobular breast cancer (LBC).
|
24493355 |
2014 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Laser capture microdissection combined with real-time polymerase chain reaction and Western blot were used to determine the expressions of Bmi-1, the cellular homologue of avian myelocytomatosis virus (c-Myc), enhancer of Zeste homolog 2 (EZH2), phosphatase and tensin homologue (PTEN) and epithelial cadherin (E-cadherin) in 20 GC specimens and the adjacent non-cancerous gastric tissues.
|
24393364 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gene-based analysis indicated a significant cumulative association of genetic variants in CDH1 with GC (all Ps <10).
|
25340495 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this report, we describe a germline CDH1 c.48 G>C variant found in a 21 year old woman and her living great uncle, who were both diagnosed with gastric cancer and belong to a family with high incidence of this type of cancer.
|
25771876 |
2014 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among these genes, the mRNA ratio of CDH2 to CDH1 could distinguish the 15 diffuse-type GC samples from the 17 intestinal-type GC samples.
|
24728500 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We have shown that germline CDH1 mutations are associated with early onset of bilateral LCIS with or without ILC in women without a family history of gastric cancer.
|
24366306 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We find associated candidate driver genes, and identify seven novel somatic mutations in CDH1, which is a well-known gastric cancer-associated gene.
|
24690483 |
2014 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 somatic alterations were found in approximately 30% of all patients with GC.
|
23341533 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To give a comprehensive report of E-cadherin gene (CDH1) variations in a population at a high risk for gastric cancer (GC).
|
23431106 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy.
|
22543498 |
2013 |