Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer.
|
23435907 |
2013 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Frequent promoter methylation of CDH1 in non-neoplastic mucosa of sporadic diffuse gastric cancer.
|
24023308 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Prophylactic total gastrectomy eliminates the risk of gastric cancer in individuals with E-cadherin gene mutations.
|
23752020 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Searching for E-cadherin gene mutations in early onset diffuse gastric cancer and hereditary diffuse gastric cancer in Korean patients.
|
23264079 |
2013 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
59 GCs, 59 first degree relatives (FDRs) of GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) and 52 blood donors (BDs) were analyzed for CDH1 by direct sequencing, structural modelling and bioinformatics.
|
24204729 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The panel felt that it is appropriate for patients with DGC to have CDH1 mutation testing in a family with (1) ≥2 cases of GC, with at least one case of DGC diagnosed before age of 50 years; (2) ≥3 cases of GC diagnosed at any age, one or more of which is DGC; (3) a patient diagnosed with DGC and lobular breast carcinoma; or (4) patients diagnosed with DGC under age of 35 years.
|
22941158 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Herein we describe the first reported case of primary appendiceal signet ring cell carcinoma arising in a CDH1-associated hereditary diffuse gastric carcinoma kindred with synchronous primary diffuse gastric carcinoma.
|
23849133 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The only gastric cancer (GC) syndrome with a proven inherited defect is designated as hereditary diffuse gastric cancer (HDGC) and is caused by germline E-cadherin/CDH1 alterations.
|
23481202 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recently, germline mutations in the E-cadherin/CDH1 gene have been identified in families with an autosomal dominant inherited predisposition to gastric cancer of the diffuse type.
|
22846738 |
2013 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Large meta-analyses confirmed the association between IL8, IL10, TNF-b, TP53 and PSCA, while genetic variation at different genes such as XPG, PLCE1, HFE, ERCC5, EZH2, DOC2, CYP19A1, ALDH2, and CDH1 have been reported to be associated with GC risk.
|
24011243 |
2013 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of CDH1 methylation in the subjects with GC was significantly lower in cancer lesion than in non cancerous mucosa, whereas that of DAPK methylation was not different.
|
23280118 |
2013 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied.
|
22936446 |
2012 |
Stomach Carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The E-cadherin protein expression level in gastric cancer tissues was significantly lower than that in the adjacent normal tissues (p < 0.05).
|
22581441 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggests that CDH1 -160 A-allele may play a protective role of stomach cancer development in Asians but not in Caucasians.
|
21625863 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 mutation testing in families with a history of gastric cancer and prophylactic gastrectomy in mutation-positive patients are recommended for the management of HDGC.
|
22160243 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results indicated that plasma CDH1 levels may serve as a risk marker against gastric cancer and variant genotypes of rs26160 and rs17690554 may contribute to the etiology of diffuse gastric cancer in this study.
|
22535324 |
2012 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
This data could open new approaches in the gastric cancer prevention test; before proposing a proband candidate for the CDH1 genetic screening, geographic variability, alongside the family history should be considered.
|
22225527 |
2012 |
Stomach Carcinoma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer.
|
22514028 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This case highlights the importance of recognition of the HDGC syndrome and of testing for CDH1 germline mutations in young individuals with diffuse gastric cancer without a family history of the disease.
|
21696387 |
2012 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
To explore germline hypermethylation of the tumor suppressor genes MLH1, CDH1 and P16(INK4a) in suspected cases of hereditary gastric cancer (GC).
|
22228973 |
2012 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
CDH1 mutation carriers have a strongly increased risk of developing gastric cancer (GC) and lobular breast cancer (LBC).
|
22020549 |
2012 |
Stomach Carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer.
|
21106365 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The majority of patients with germline CDH1 mutation have foci of noninvasive or invasive gastric cancer by middle age.
|
20719348 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Participants included one 37-year-old man with multiple polyps in his stomach and a family history of stomach cancer, one 18 year-old man with a confirmed CDH1 mutation and a family history of stomach cancer, and one 33-year-old man with confirmed metastatic gastric adenocarcinoma.
|
21838951 |
2011 |
Stomach Carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations of the E-cadherin gene in families with inherited invasive lobular breast carcinoma but no diffuse gastric cancer.
|
21271559 |
2011 |