TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs11178997
rs11178997 		0.827 0.040 12 71938373 upstream gene variant T/A snv 0.12
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		Mental Disorders 0.010 1.000 1 2015 2015
dbSNP: rs11178998
rs11178998 		1.000 0.040 12 71938935 5 prime UTR variant A/G snv 5.7E-02
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs11178999
rs11178999 		12 71939790 intron variant G/A snv 0.27
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2019 2019
dbSNP: rs11179000
rs11179000 		0.925 0.040 12 71944848 intron variant A/T snv 0.31
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		Mental Disorders 0.010 < 0.001 1 2006 2006
dbSNP: rs11179000
rs11179000 		0.925 0.040 12 71944848 intron variant A/T snv 0.31
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2011 2011
dbSNP: rs11179027
rs11179027 		1.000 0.040 12 71983532 intron variant G/C snv 0.26
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0588008
Disease: Severe depression
Severe depression 		Mental Disorders 0.010 1.000 1 2019 2019
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2013 2013
dbSNP: rs120074175
rs120074175 		0.827 0.080 12 72031544 missense variant G/A snv 1.2E-05 7.0E-06
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2013 2013
dbSNP: rs12229394
rs12229394 		0.925 0.080 12 71999134 intron variant G/A snv 0.29
CUI: C0344315
Disease: Depressed mood
Depressed mood 		Behavior and Behavior Mechanisms 0.010 1.000 1 2010 2010
dbSNP: rs12229394
rs12229394 		0.925 0.080 12 71999134 intron variant G/A snv 0.29
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		Mental Disorders 0.010 1.000 1 2010 2010
dbSNP: rs12229394
rs12229394 		0.925 0.080 12 71999134 intron variant G/A snv 0.29
CUI: C0011570
Disease: Mental Depression
Mental Depression 		Behavior and Behavior Mechanisms 0.010 1.000 1 2010 2010
dbSNP: rs1317926854
rs1317926854 		1.000 0.040 12 72031625 missense variant A/G snv
CUI: C1842981
Disease: NEUROTICISM
NEUROTICISM 		Behavior and Behavior Mechanisms 0.010 1.000 1 2011 2011
dbSNP: rs1386482
rs1386482 		0.827 0.080 12 72018792 intron variant T/G snv 0.52
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386482
rs1386482 		0.827 0.080 12 72018792 intron variant T/G snv 0.52
CUI: C1852197
Disease: MAJOR AFFECTIVE DISORDER 1
MAJOR AFFECTIVE DISORDER 1 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386482
rs1386482 		0.827 0.080 12 72018792 intron variant T/G snv 0.52
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386482
rs1386482 		0.827 0.080 12 72018792 intron variant T/G snv 0.52
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386482
rs1386482 		0.827 0.080 12 72018792 intron variant T/G snv 0.52
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C0564567
Disease: Impulsive character (finding)
Impulsive character (finding) 		0.010 1.000 1 2012 2012
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C1839839
Disease: MAJOR AFFECTIVE DISORDER 2
MAJOR AFFECTIVE DISORDER 2 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C0030319
Disease: Panic Disorder
Panic Disorder 		Mental Disorders 0.010 1.000 1 2007 2007
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C0021125
Disease: Impulsive Behavior
Impulsive Behavior 		Behavior and Behavior Mechanisms 0.010 1.000 1 2009 2009
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C1970943
Disease: MAJOR AFFECTIVE DISORDER 4
MAJOR AFFECTIVE DISORDER 4 		Mental Disorders 0.010 1.000 1 2009 2009
dbSNP: rs1386483
rs1386483 		0.790 0.080 12 72018714 intron variant T/C snv 0.53
CUI: C1970945
Disease: MAJOR AFFECTIVE DISORDER 6
MAJOR AFFECTIVE DISORDER 6 		Mental Disorders 0.010 1.000 1 2009 2009