TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C4016417
Disease: VASCULAR DEMENTIA, SUSCEPTIBILITY TO
VASCULAR DEMENTIA, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs1799724
rs1799724 		0.600 0.680 6 31574705 upstream gene variant C/T snv 8.5E-02
CUI: C1856170
Disease: ALZHEIMER DISEASE, SUSCEPTIBILITY TO
ALZHEIMER DISEASE, SUSCEPTIBILITY TO 		0.700 0
dbSNP: rs281865419
rs281865419 		6 31577157 missense variant C/T snv 8.1E-06 7.0E-06
CUI: C4016415
Disease: TNF RECEPTOR BINDING, ALTERED
TNF RECEPTOR BINDING, ALTERED 		0.700 0
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0030286
Disease: Pancreatic Diseases
Pancreatic Diseases 		Digestive System Diseases 0.010 < 0.001 1 2017 2017
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0339470
Disease: Visually threatening diabetic retinopathy
Visually threatening diabetic retinopathy 		Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases 0.010 < 0.001 1 2016 2016
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C3853540
Disease: Aspirin exacerbated respiratory disease
Aspirin exacerbated respiratory disease 		Pathological Conditions, Signs and Symptoms; Infections; Respiratory Tract Diseases; Immune System Diseases; Chemically-Induced Disorders; Otorhinolaryngologic Diseases 0.010 < 0.001 1 2017 2017
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		Digestive System Diseases; Neoplasms 0.010 < 0.001 1 2016 2016
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0343641
Disease: Human papilloma virus infection
Human papilloma virus infection 		Infections 0.010 < 0.001 1 2012 2012
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0014544
Disease: Epilepsy
Epilepsy 		Nervous System Diseases 0.010 < 0.001 1 2012 2012
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		Digestive System Diseases; Neoplasms 0.010 < 0.001 1 2016 2016
dbSNP: rs361525
rs361525 		0.562 0.760 6 31575324 upstream gene variant G/A snv 4.6E-02
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		Neoplasms 0.010 < 0.001 1 2016 2016
dbSNP: rs361525
rs361525 		0.562 0.760 6 31575324 upstream gene variant G/A snv 4.6E-02
CUI: C0018213
Disease: Graves Disease
Graves Disease 		Eye Diseases; Immune System Diseases; Endocrine System Diseases 0.010 < 0.001 1 2018 2018
dbSNP: rs361525
rs361525 		0.562 0.760 6 31575324 upstream gene variant G/A snv 4.6E-02
CUI: C0339470
Disease: Visually threatening diabetic retinopathy
Visually threatening diabetic retinopathy 		Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases 0.010 < 0.001 1 2016 2016
dbSNP: rs361525
rs361525 		0.562 0.760 6 31575324 upstream gene variant G/A snv 4.6E-02
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		Neoplasms 0.010 < 0.001 1 2016 2016
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0585442
Disease: Osteosarcoma of bone
Osteosarcoma of bone 		Neoplasms 0.010 < 0.001 1 2017 2017
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0154723
Disease: Migraine with Aura
Migraine with Aura 		Nervous System Diseases 0.010 < 0.001 1 2010 2010
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		Eye Diseases; Endocrine System Diseases; Cardiovascular Diseases 0.010 < 0.001 1 2006 2006
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma 		Neoplasms 0.010 < 0.001 1 2017 2017
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		Cardiovascular Diseases 0.010 < 0.001 1 2005 2005
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0033893
Disease: Tension Headache
Tension Headache 		Nervous System Diseases 0.010 < 0.001 1 2010 2010
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C1332986
Disease: Childhood Osteosarcoma
Childhood Osteosarcoma 		Neoplasms 0.010 < 0.001 1 2017 2017
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0679408
Disease: Lesion of stomach
Lesion of stomach 		Digestive System Diseases 0.010 < 0.001 1 2013 2013
dbSNP: rs763000109
rs763000109 		0.827 0.240 6 31575788 missense variant C/G;T snv 4.1E-06; 1.6E-05
CUI: C0014175
Disease: Endometriosis
Endometriosis 		Female Urogenital Diseases and Pregnancy Complications 0.010 < 0.001 1 2013 2013
dbSNP: rs745738344
rs745738344 		0.653 0.600 6 31576786 synonymous variant G/A snv 1.6E-05 1.4E-05
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		Nervous System Diseases 0.030 0.333 3 2010 2014
dbSNP: rs1800629
rs1800629 		0.472 0.920 6 31575254 upstream gene variant G/A snv 0.12 0.14
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		Nutritional and Metabolic Diseases; Immune System Diseases; Endocrine System Diseases 0.040 0.500 4 2006 2019