TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Variant DSI v DPI v Chr Position Consequence Alleles Class AF EXOME AF GENOME Disease Disease Class Score vda EI vda N. PMIDs First Ref. Last Ref.
dbSNP: rs1330189219
rs1330189219 		0.882 0.080 6 31573570 synonymous variant C/T snv 4.0E-06
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		Neoplasms; Respiratory Tract Diseases 0.010 1.000 1 2008 2008
dbSNP: rs1400328611
rs1400328611 		1.000 0.080 6 31575804 frameshift variant AG/- del
CUI: C0281899
Disease: Prolapsed lumbar disc
Prolapsed lumbar disc 		Pathological Conditions, Signs and Symptoms; Musculoskeletal Diseases 0.010 1.000 1 2011 2011
dbSNP: rs1418646618
rs1418646618 		1.000 0.080 6 31575843 missense variant C/G snv 1.2E-05 7.0E-06
CUI: C0024534
Disease: Malaria, Cerebral
Malaria, Cerebral 		Infections; Nervous System Diseases 0.010 1.000 1 2013 2013
dbSNP: rs35131721
rs35131721 		1.000 0.080 6 31576538 missense variant C/T snv 3.2E-05 2.8E-05
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		Digestive System Diseases; Neoplasms 0.010 1.000 1 2011 2011
dbSNP: rs548532642
rs548532642 		0.882 0.080 6 31577184 missense variant G/A;T snv 1.6E-05
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		Digestive System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs548532642
rs548532642 		0.882 0.080 6 31577184 missense variant G/A;T snv 1.6E-05
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		Digestive System Diseases 0.010 1.000 1 2006 2006
dbSNP: rs548532642
rs548532642 		0.882 0.080 6 31577184 missense variant G/A;T snv 1.6E-05
CUI: C1304140
Disease: Familial psoriasis
Familial psoriasis 		Skin and Connective Tissue Diseases 0.010 1.000 1 2012 2012
dbSNP: rs673
rs673 		0.882 0.080 6 31575318 upstream gene variant G/A snv 1.8E-02
CUI: C4048328
Disease: cervical cancer
cervical cancer 		Neoplasms; Female Urogenital Diseases and Pregnancy Complications 0.010 1.000 1 2018 2018
dbSNP: rs673
rs673 		0.882 0.080 6 31575318 upstream gene variant G/A snv 1.8E-02
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		Neoplasms; Female Urogenital Diseases and Pregnancy Complications 0.010 1.000 1 2018 2018
dbSNP: rs673
rs673 		0.882 0.080 6 31575318 upstream gene variant G/A snv 1.8E-02
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		Neoplasms; Female Urogenital Diseases and Pregnancy Complications 0.010 1.000 1 2018 2018
dbSNP: rs673
rs673 		0.882 0.080 6 31575318 upstream gene variant G/A snv 1.8E-02
CUI: C0149931
Disease: Migraine Disorders
Migraine Disorders 		Nervous System Diseases 0.010 1.000 1 2009 2009
dbSNP: rs1250554906
rs1250554906 		1.000 0.120 6 31576808 missense variant G/A snv 4.1E-06 7.0E-06
CUI: C0393814
Disease: Hereditary liability to pressure palsies
Hereditary liability to pressure palsies 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Musculoskeletal Diseases; Nervous System Diseases 0.010 1.000 1 2014 2014
dbSNP: rs4645843
rs4645843 		1.000 0.120 6 31576785 missense variant C/G;T snv 2.6E-03
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		Neoplasms; Female Urogenital Diseases and Pregnancy Complications; Endocrine System Diseases 0.010 1.000 1 2017 2017
dbSNP: rs1363819544
rs1363819544 		1.000 0.160 6 31577126 synonymous variant A/G snv 7.0E-06
CUI: C0522624
Disease: Subcutaneous panniculitis-like T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma 		Neoplasms; Skin and Connective Tissue Diseases; Immune System Diseases; Hemic and Lymphatic Diseases 0.010 1.000 1 2018 2018
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C1836232
Disease: ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO 		0.700 1.000 2 2009 2010
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C1836231
Disease: HIV-1, RESISTANCE TO
HIV-1, RESISTANCE TO 		0.700 1.000 2 2009 2010
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C1836230
Disease: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO 		0.700 1.000 2 2009 2010
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C1836233
Disease: AIDS, PROGRESSION TO
AIDS, PROGRESSION TO 		0.700 1.000 2 2009 2010
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0003467
Disease: Anxiety
Anxiety 		Behavior and Behavior Mechanisms 0.010 1.000 1 2016 2016
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome 		Infections; Immune System Diseases 0.700 1.000 1 2009 2009
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		Infections 0.010 1.000 1 2011 2011
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0003469
Disease: Anxiety Disorders
Anxiety Disorders 		Mental Disorders 0.010 1.000 1 2016 2016
dbSNP: rs3093662
rs3093662 		0.851 0.200 6 31576412 intron variant A/G snv 7.1E-02
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		Skin and Connective Tissue Diseases; Musculoskeletal Diseases; Immune System Diseases 0.700 1.000 1 2007 2007
dbSNP: rs370893734
rs370893734 		1.000 0.200 6 31577481 missense variant G/A;T snv 2.0E-05; 1.6E-05
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Eye Diseases; Skin and Connective Tissue Diseases; Stomatognathic Diseases; Cardiovascular Diseases 0.010 1.000 1 2007 2007
dbSNP: rs763000109
rs763000109 		0.827 0.240 6 31575788 missense variant C/G;T snv 4.1E-06; 1.6E-05
CUI: C0028754
Disease: Obesity
Obesity 		Pathological Conditions, Signs and Symptoms; Nutritional and Metabolic Diseases 0.010 1.000 1 2019 2019