|
rs1420101
|
IL18R1;IL1RL1
|
Eosinophil count procedure
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
|
19198610 |
2009 |
|
rs1420101
|
IL18R1;IL1RL1
|
Eosinophil count procedure
|
A |
0.800 |
GeneticVariation |
GWASDB |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
|
19198610 |
2009 |
|
rs10204137
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
|
rs10208293
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
|
rs13431828
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
|
rs2160203
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
|
rs4988957
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
|
rs1420101
|
IL18R1;IL1RL1
|
Nasal Polyps
|
|
0.710 |
GeneticVariation |
BEFREE |
Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP.
|
19860791 |
2010 |
|
rs1420101
|
IL18R1;IL1RL1
|
Eosinophilic disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF.
|
19860791 |
2010 |
|
rs1420101
|
IL18R1;IL1RL1
|
Eosinophilia
|
|
0.010 |
GeneticVariation |
BEFREE |
We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF.
|
19860791 |
2010 |
|
rs10192157
|
IL18R1;IL1RL1
|
Asthma
|
|
0.710 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs10204137
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs10206753
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs13431828
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
|
rs1041973
|
IL18R1;IL1RL1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90).
|
21281963 |
2011 |
|
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs10173081
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs13408569
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs13431828
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
|
rs1420101
|
IL18R1;IL1RL1
|
Bronchiolitis
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the association between RSV and 3 selected IL1RL1 single-nucleotide polymorphisms rs1921622, rs11685480 or rs1420101 in 81 ventilated and 384 non-ventilated children under 1 year of age hospitalized with primary RSV bronchiolitis in comparison to 930 healthy controls.
|
22574108 |
2012 |
|
rs1921622
|
IL18R1;IL1RL1
|
Bronchiolitis
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a genetic link between rs1921622 IL1RL1 polymorphism and disease severity in RSV bronchiolitis.
|
22574108 |
2012 |