IL1RL1, interleukin 1 receptor like 1, 9173

N. diseases: 117; N. variants: 51
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10173081
rs10173081
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		T 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs10173081
rs10173081
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.710 GeneticVariation BEFREE However, the rs10192157 and rs2899642 mutations were documented with asthma disease. 31213409 2020
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.710 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		T 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		A 0.810 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.810 GeneticVariation BEFREE However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		G 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0018621
Disease:
Hay fever 		A 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
dbSNP: rs10204137
rs10204137
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs10204137
rs10204137
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010278
Disease:
Craniosynostosis 		0.010 GeneticVariation BEFREE Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03). 19671251 2009
dbSNP: rs10206753
rs10206753
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs10206753
rs10206753
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		C 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		G 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0264408
Disease:
Childhood asthma 		G 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		G 0.700 GeneticVariation GWASCAT Identification of a new locus at 16q12 associated with time to asthma onset. 27130862 2016
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		A 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010278
Disease:
Craniosynostosis 		0.010 GeneticVariation BEFREE Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03). 19671251 2009
dbSNP: rs1041973
rs1041973
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.010 GeneticVariation BEFREE In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90). 21281963 2011
dbSNP: rs10865050
rs10865050
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		G 0.700 GeneticVariation GWASCAT Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. 29083406 2017
dbSNP: rs11123923
rs11123923
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		A 0.700 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs11676124
rs11676124
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576 2018
dbSNP: rs11685424
rs11685424
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE One tag SNP in each gene was significantly associated with CAD (rs7025417(T) in IL33, padj = 1.19 × 10(-28), OR = 1.39, 95% CI: 1.31-1.47; rs11685424(G) in IL1RL1, padj = 6.93 × 10(-30), OR = 1.40, 95% CI: 1.32-1.48). 24075188 2013
dbSNP: rs11685424
rs11685424
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0085580
Disease:
Essential Hypertension 		0.010 GeneticVariation BEFREE Our study showed that variants rs11685424, rs12999364 and rs3821204 are highly associated with an increase in risk of EH, while rs6543116 is associated with a decrease risk of EH. 28121058 2017