rs1420101
|
IL18R1;IL1RL1
|
Eosinophil count procedure
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
|
19198610 |
2009 |
rs1420101
|
IL18R1;IL1RL1
|
Eosinophil count procedure
|
A |
0.800 |
GeneticVariation |
GWASDB |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
|
19198610 |
2009 |
rs10204137
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
rs10208293
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
rs13431828
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
rs2160203
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
rs4988957
|
IL18R1;IL1RL1
|
Craniosynostosis
|
|
0.010 |
GeneticVariation |
BEFREE |
Statistically significant allelic associations with CRS were noted for 5 SNPs (rs10204137, p = 0.04; rs10208293, p = 0.03; rs13431828, p = 0.008; rs2160203, p = 0.03, and rs4988957, p = 0.03).
|
19671251 |
2009 |
rs10192157
|
IL18R1;IL1RL1
|
Asthma
|
|
0.710 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs1420101
|
IL18R1;IL1RL1
|
Nasal Polyps
|
|
0.710 |
GeneticVariation |
BEFREE |
Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP.
|
19860791 |
2010 |
rs10204137
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs10206753
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs13431828
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs1420101
|
IL18R1;IL1RL1
|
Eosinophilic disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF.
|
19860791 |
2010 |
rs1420101
|
IL18R1;IL1RL1
|
Eosinophilia
|
|
0.010 |
GeneticVariation |
BEFREE |
We recruited 284 patients with NP in four participating hospitals in Belgium and 427 healthy controls, and genotyped 10 SNPs affecting eosinophilia (rs1420101 in IL1RL1, rs12619285 in IKZF2, rs4431128 in GATA2, rs4143832 in IL5, rs3184504 in SH2B3, rs2416257 in WDR36, rs2269426 in MHC, rs9494145 in MYB, rs748065 in GFRA2, and rs3939286 in IL33) using MALDI-TOF.
|
19860791 |
2010 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs10173081
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs13408569
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs13431828
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs1041973
|
IL18R1;IL1RL1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90).
|
21281963 |
2011 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
G |
0.810 |
GeneticVariation |
GWASCAT |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |