IL1RL1, interleukin 1 receptor like 1, 9173

N. diseases: 117; N. variants: 51
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.820 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.820 GeneticVariation BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.820 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.820 GeneticVariation BEFREE Association of IL1RL1 rs3771180 and TSLP rs1837253 variants with asthma in the Guangxi Zhuang population in China. 31066119 2019
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.810 GeneticVariation BEFREE However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011
dbSNP: rs13408661
rs13408661
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs13408661
rs13408661
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.810 GeneticVariation BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
dbSNP: rs950881
rs950881
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction 		0.800 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.710 GeneticVariation BEFREE However, the rs10192157 and rs2899642 mutations were documented with asthma disease. 31213409 2020
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.710 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.710 GeneticVariation BEFREE Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).<i>IL1RL1</i> asthma-risk SNPs strongly associated with <i>IL1RL1</i> methylation (rs1420101; p=3.7×10<sup>-16</sup>) and serum IL1RL1-a levels (p=2.8×10<sup>-56</sup>). 29519908 2018
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0027430
Disease:
Nasal Polyps 		0.710 GeneticVariation BEFREE Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP. 19860791 2010
dbSNP: rs10173081
rs10173081
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs10204137
rs10204137
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs10206753
rs10206753
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs12470864
rs12470864
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C0741260
Disease:
Adult onset asthma 		0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
dbSNP: rs12470864
rs12470864
Entrez Id: 9173
Gene Symbol: IL1RL1
IL1RL1
CUI: C4553157
Disease:
Interleukin 1 Receptor-Like 1 Measurement 		0.700 GeneticVariation GWASCAT Connecting genetic risk to disease end points through the human blood plasma proteome. 28240269 2017
dbSNP: rs13001325
rs13001325
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0010346
Disease:
Crohn Disease 		0.700 GeneticVariation GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
dbSNP: rs13001325
rs13001325
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0021390
Disease:
Inflammatory Bowel Diseases 		0.700 GeneticVariation GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
dbSNP: rs13408569
rs13408569
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs13431828
rs13431828
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs13431828
rs13431828
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma 		0.700 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs1861245
rs1861245
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0264408
Disease:
Childhood asthma 		0.700 GeneticVariation GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
dbSNP: rs59185885
rs59185885
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0035242
Disease:
Respiratory Tract Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019