|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
Acute-On-Chronic Liver Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
Idiopathic Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 L412F was also associated with a significantly greater risk of mortality and an accelerated decline in FVC in patients with IPF.
|
24070541 |
2013 |
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multivariate analysis, TLR3 L412F was significantly associated with chronic hepatitis C (odds ratio: 1.73, 95% confidence interval [CI]: 1.13-2.65, P = 0.01).
|
23240626 |
2013 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
HIV-1 infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
Myocarditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
HIV Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 T allele has a protective effect against HIV infection among HESNs IDUs.
|
23962581 |
2013 |
|
Lichen Planus, Oral
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene.
|
24028589 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control.
|
24408902 |
2014 |
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant increase in oral cancer risk was observed in individuals with mutated genotype of TLR3 rs3775291 polymorphism (OR = 1.096, P = 0.036) compared to wild-type.
|
23796347 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant increase in oral cancer risk was observed in individuals with mutated genotype of TLR3 rs3775291 polymorphism (OR = 1.096, P = 0.036) compared to wild-type.
|
23796347 |
2014 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant associations with cancer risk were observed for single nucleotide polymorphisms (SNPs) rs3775291 (allele model: odds ratio (OR) = 1.12, 95 % confidence interval (95 % CI) = 1.00-1.25, P = 0.04), rs3775290 (allele model: OR = 1.12, 95 % CI = 1.00-1.25, P = 0.04; dominant model: OR = 1.30, 95 % CI = 1.05-1.60, P = 0.01; homozygous comparison: OR = 1.68, 95 % CI = 1.06-2.68, P = 0.03; heterozygous comparison: OR = 1.25, 95 % CI = 1.01-1.55, P = 0.04), rs5743305 (allele model: OR = 1.07, 95 % CI = 1.01-1.15, P = 0.03; dominant model: OR = 1.11, 95 % CI = 1.01-1.22, P = 0.03), and rs5743312 (allele model: OR = 1.13, 95 % CI = 1.01-1.27, P = 0.03; recessive model: OR = 1.86, 95 % CI = 1.31-2.63, P < 0.01; homozygous comparison: OR = 1.88, 95 % CI = 1.33-2.67, P < 0.01), respectively.
|
24819172 |
2014 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant associations with cancer risk were observed for single nucleotide polymorphisms (SNPs) rs3775291 (allele model: odds ratio (OR) = 1.12, 95 % confidence interval (95 % CI) = 1.00-1.25, P = 0.04), rs3775290 (allele model: OR = 1.12, 95 % CI = 1.00-1.25, P = 0.04; dominant model: OR = 1.30, 95 % CI = 1.05-1.60, P = 0.01; homozygous comparison: OR = 1.68, 95 % CI = 1.06-2.68, P = 0.03; heterozygous comparison: OR = 1.25, 95 % CI = 1.01-1.55, P = 0.04), rs5743305 (allele model: OR = 1.07, 95 % CI = 1.01-1.15, P = 0.03; dominant model: OR = 1.11, 95 % CI = 1.01-1.22, P = 0.03), and rs5743312 (allele model: OR = 1.13, 95 % CI = 1.01-1.27, P = 0.03; recessive model: OR = 1.86, 95 % CI = 1.31-2.63, P < 0.01; homozygous comparison: OR = 1.88, 95 % CI = 1.33-2.67, P < 0.01), respectively.
|
24819172 |
2014 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients.
|
25766991 |
2015 |
|
Japanese Encephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significantly higher frequency of Leu412Phe polymorphism was noted in JE patients as compared with healthy controls [mutant (TT) genotype, P-value=0.019; mutant (TT)+heterozygous (CT) genotype, P-value=0.013].
|
26298326 |
2015 |
|
Pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding severity, CC genotype patients in TLR3 rs3775291 had an increased risk for severe pancreatitis (CC odds ratio [OR], 2.426; P = 0.015).
|
25423559 |
2015 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Sarcoidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that TLR3 SNP rs3775291 may affect cardiac involvement in Japanese patients with sarcoidosis.
|
25720507 |
2015 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Severe Dengue
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF.
|
25446400 |
2015 |
|
Dengue Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF.
|
25446400 |
2015 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT).
|
25992926 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11-2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16-0.25]).
|
27227908 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed donor age older than 40 yr (OR=2.93; 95% CI = 1.49-5.8, p = 0.002) and the TLR3 Leu412Phe CC genotype (OR=2.02, 95%CI=1.01-4.05, p = 0.046) were independently associated with severe HCV recurrence.
|
27101936 |
2016 |