|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
HIV-1 infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
Myocarditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
HIV Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 T allele has a protective effect against HIV infection among HESNs IDUs.
|
23962581 |
2013 |
|
Lichen Planus, Oral
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene.
|
24028589 |
2013 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Herpes Labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the TLR3 L412F genetic polymorphism was found to reduce NK cell TLR3-responsiveness and is associated with susceptibility to recurrent HL.
|
22537752 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01).
|
21412764 |
2012 |
|
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity.
|
22024499 |
2012 |
|
Virus Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility.
|
22174453 |
2012 |
|
Cutaneous Candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.
|
22024499 |
2012 |
|
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
|
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
|
Chronic candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
|
Recurrent herpes simplex labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.
|
22537752 |
2012 |
|
Polypoidal choroidal vasculopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicates that the TLR3 rs3775291 gene polymorphism is not associated with CNV and PCV in Singaporean Chinese patients.
|
21079408 |
2011 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events).
|
21239167 |
2011 |
|
Subacute Sclerosing Panencephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of 412Phe allele of TLR3 rs3775291 in SSPE patients was significantly higher than that in controls (P=.03).
|
19016379 |
2008 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection.
|
30143709 |
2018 |
|
Hepatitis B, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 A allele was associated with a reduced likelihood of spontaneous HBsAg SC and HBeAg SC, and an increased risk of developing chronic hepatitis B.
|
30143709 |
2018 |
|
Tick-Borne Encephalitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms rs3775291, rs5743305 (associated with TLR3 expression), and rs755622 (associated with MIF expression) were assessed in blood samples from 108 TBE patients and 72 non-TBE controls.
|
28646884 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of the TLR3 variants, rs13126816 and rs3775291, with the autoimmune endocrine disorders, Addison's disease (AD) and type 1 diabetes (T1D) in the Polish population.
|
26318769 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control.
|
24408902 |
2014 |
|
Tick-Borne Encephalitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that the G allele (within the G/G homozygous genotype) of the TLR3 rs3775291 SNP is associated with predisposition to TBE in the Russian population.
|
23721942 |
2013 |