Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
TACR3 P29371 tachykinin receptor 3 G-protein coupled receptor 1.8E-17 0.553 0.769 5
OPRM1 P35372 opioid receptor mu 1 G-protein coupled receptor 7.9E-11 0.457 0.808 7
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
PTGS1 P23219 prostaglandin-endoperoxide synthase 1 Enzyme 6.2E-07 0.460 0.885 18
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 25
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923 7
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 14
AIF1 P55008 allograft inflammatory factor 1 Calcium-binding protein 1.9E-06 0.521 0.808 17
CCKBR P32239 cholecystokinin B receptor G-protein coupled receptor 2.1E-06 0.573 0.615 10
CNR2 P34972 cannabinoid receptor 2 G-protein coupled receptor 6.5E-06 0.509 0.846 6
PPP1R9A Q9ULJ8 protein phosphatase 1 regulatory subunit 9A 1.1E-05 0.769 0.269 7
CCK P06307 cholecystokinin 3.3E-05 0.453 0.846 4
CASP1 P29466 caspase 1 Enzyme 3.5E-05 0.413 0.885 8
TACR1 P25103 tachykinin receptor 1 G-protein coupled receptor 3.8E-04 0.502 0.885 15
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
OPRD1 P41143 opioid receptor delta 1 G-protein coupled receptor 3.3E-03 0.604 0.731 5
BDKRB1 P46663 bradykinin receptor B1 G-protein coupled receptor 4.7E-03 0.619 0.731 16
CCL22 O00626 C-C motif chemokine ligand 22 Signaling 8.4E-03 0.500 0.846 6
CCR2 P41597 C-C motif chemokine receptor 2 2.3E-02 0.418 0.846 7
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 27
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 40
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 54