Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 82
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 76
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885 69
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 64
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 54
CCL5 P13501 C-C motif chemokine ligand 5 Signaling 1.8E-03 0.403 0.885 40
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 40
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 40
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 35
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 27
CX3CR1 P49238 C-X3-C motif chemokine receptor 1 G-protein coupled receptor 6.1E-02 0.457 0.885 26
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 25
NGF P01138 nerve growth factor Signaling 0.82 0.391 0.885 24
NGFR P08138 nerve growth factor receptor Receptor 9.8E-02 0.477 0.846 23
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 23
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 19
PTGS1 P23219 prostaglandin-endoperoxide synthase 1 Enzyme 6.2E-07 0.460 0.885 18
AIF1 P55008 allograft inflammatory factor 1 Calcium-binding protein 1.9E-06 0.521 0.808 17
BDKRB1 P46663 bradykinin receptor B1 G-protein coupled receptor 4.7E-03 0.619 0.731 16
TACR1 P25103 tachykinin receptor 1 G-protein coupled receptor 3.8E-04 0.502 0.885 15
ALOX5 P09917 arachidonate 5-lipoxygenase Enzyme 1.2E-06 0.447 0.885 14
TJP1 Q07157 tight junction protein 1 Cell-cell junction 1.00 0.576 0.692 11
CCKBR P32239 cholecystokinin B receptor G-protein coupled receptor 2.1E-06 0.573 0.615 10
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 9