|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 34 white patients with established mild to moderate essential hypertension (World Health Organization stage I or II, mean age 52 +/- 9 years) genotype analysis of GNB3 C825T polymorphism, insertion/deletion polymorphism of the ACE gene and 1166 A/C polymorphism of the AT1 receptor gene was performed.
|
10526907 |
1999 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a C825T polymorphism in the gene coding for the beta3 subunit of G proteins (GNB3) has been described in cells from patients with essential hypertension and enhanced Na+/H+ exchange activity.
|
12113397 |
2002 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
G-protein beta 3 subunit (GNB3) C825T (rs5443) single nucleotide polymorphism (SNP) has been implicated as a risk factor for essential hypertension in the general population.
|
19811352 |
2009 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GNB3 C825T splice variant is associated with the DBP-lowering effect of telmisartan but not amlodipine in Chinese EH patients.
|
26712426 |
2016 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
|
25280441 |
2014 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death.
|
28067546 |
2017 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association of insulin sensitivity with the c.825C>T variant of the g-protein beta-3 subunit (GNB3), a candidate gene of hypertension, in families of Mexican-American hypertensive patients.
|
18413224 |
2008 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistical significant association between hypertension and the C825T polymorphism was found during the follow-up.
|
20539277 |
2010 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the C825T polymorphism of the beta 3 subunit of G protein is significantly and independently associated with the occurrence of hypertension in the study population.
|
29853161 |
2018 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C825T polymorphism in the gene GNB3, which encodes the beta 3 subunit of heterotrimeric G proteins, was identified in cell lines from patients with hypertension.
|
15660499 |
2005 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension.
|
12011775 |
2002 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
GNB3 gene C825T and ACE gene I/D polymorphisms in essential hypertension in a Kazakh genetic isolate.
|
15042113 |
2004 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The T allele of the G protein beta3 subunit (GNB3) C825T polymorphism has been associated with increased signal transduction, increased activity of the kidney Na+/H+ exchanger, and also with late-onset essential hypertension.
|
15200440 |
2004 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent study has revealed that a novel variant (C825T) in exon 10 of the gene encoding the beta3 subunit of heterotrimetric G proteins (GNB3) is a genetic factor predisposing to hypertension in Caucasians.
|
10701813 |
2000 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T variant of the G-protein beta3 subunit (GNB3) gene has attracted renewed attention as a candidate gene for obesity, hypertension and hyperuricemia.
|
16707857 |
2006 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
|
21364877 |
2011 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity.
|
10477144 |
1999 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 825T-allele of the C825T polymorphism in GNB3, the gene for the G protein beta3 subunit, has been reported to be associated with essential hypertension and obesity.
|
12730030 |
2003 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings suggest that the variation within the GNB3 gene may interact with physical activity level to influence obesity status and, together with obesity and physical activity, the GNB3 825C>T variant may influence hypertension prevalence in AAs.
|
17299380 |
2007 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14,094 cases and 17,760 controls.
|
17278960 |
2007 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The further adjustment for hypertension abolished the association between the GNB3 C825T variant and DPN (OR = 1.95, p = 0.18).
|
19597293 |
2009 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G-protein beta3 subunit (GNB3) C825T polymorphism was detected through a classical candidate gene approach using cell lines with enhanced G-protein activation from patients with essential hypertension.
|
12530935 |
2003 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A C825T polymorphism of a gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder.
|
12075862 |
2002 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese.
|
24346074 |
2013 |