|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the C825T polymorphism of the beta 3 subunit of G protein is significantly and independently associated with the occurrence of hypertension in the study population.
|
29853161 |
2018 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the associations of two obesity-associated genes, FTO (rs9939609) and GNB3 (rs5443) single nucleotide polymorphisms (SNPs), with early pregnancy body mass index, gestational weight gain, and postpartum weight retention.
|
29469022 |
2018 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There have been few studies investigating interactions of G-protein beta3 subunit (<i>GNB3</i>) C825T (rs5443) and dietary sodium intake on the risk of hypertension, i.e., BP salt sensitivity.
|
29848945 |
2018 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the current study, 729 patients (CC, n = 332; CT, n = 313; TT, n = 84) with essential hypertension were genotyped for C825T polymorphism of the GNB3 gene and followed 8 years for major adverse cardiovascular events (MACEs) which include stroke, the onset of coronary artery disease (CAD), and all-cause death.
|
28067546 |
2017 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, the present meta-analysis indicated the GNB3 C825T polymorphism is related to increased EH exclusively in Caucasians.
|
28540932 |
2017 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with obesity.
|
29206867 |
2017 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GNB3 C825T splice variant is associated with the DBP-lowering effect of telmisartan but not amlodipine in Chinese EH patients.
|
26712426 |
2016 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Synergistic Effects of ACE Insertion/Deletion and GNB3 C825T Polymorphisms on the Efficacy of PDE-5 Inhibitor in Patients with Pulmonary Hypertension.
|
26821322 |
2016 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the associations between the GNB3 C825T polymorphism and obesity-related metabolic risk factors among Korean obese women.
|
25280441 |
2014 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index.
|
24827746 |
2014 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the gene encoding the human G protein beta-3 subunit (GNB3) is associated with hypertension and obesity.
|
25463071 |
2014 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese.
|
24346074 |
2013 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The TT genotype of the C825T GNB3 gene polymorphism was found to be a significant risk factor for the incidence of CVD and stroke independent of hypertension and other established CVD risk factors in a Japanese population.
|
23595158 |
2013 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C825T polymorphism of the G-protein β3 subunit gene and its association with hypertension and stroke: an updated meta-analysis.
|
23799054 |
2013 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed whether distributions of 3 single nucleotide polymorphisms in genes coding for components of G protein signaling pathways that have been associated with hypertension differ between women with preeclampsia and normotensive pregnant women; the G protein β3 subunit gene (GNB3) C825T polymorphism (rs5443), the angiotensin II type 1 receptor gene (AGTR1) 3'UTR A1166C polymorphism (rs5186), and the regulator of G protein signaling 2 gene (RGS2) 3'UTR C1114G polymorphism (rs4606).
|
23339167 |
2013 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs2301339 is perfectly linked in linkage disequilibrium (LD) with C825T (rs5443) which has been associated with hypertension in Caucasian, but inconsistent in Asian populations.
|
22534794 |
2012 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant association identified between GNB3-C825T polymorphism and EH in Han Chinese population.
|
22714918 |
2012 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our overall results suggest null association of α-adducin G460T and GNB3 C825T polymorphisms with hypertension in Chinese but indicate local marginal significance of C825T, as a putative salt-sensitive switch, in southern Chinese.
|
21364877 |
2011 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
T allele frequency in overall population showed significant association with hypertension for C825T (0.0134).
|
21473734 |
2011 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression.
|
21709600 |
2011 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistical significant association between hypertension and the C825T polymorphism was found during the follow-up.
|
20539277 |
2010 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |