|
rs5443
|
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphisms rs2241766 and rs5443 were found to potentially be associated with GDM; moreover, a positive interaction was demonstrated between rs2241766 and age, and a negative interaction was demonstrated with weight gain of ≥10 kg before 24-week gestation.
|
29519182 |
2019 |
|
rs5443
|
|
Epigastric pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a subgroup analysis, only minor allele (T) in GNB3 825C>T was associated with an increased susceptibility to the epigastric pain syndrome subtype (OR = 1.34, 95% CI 1.10-1.63, <i>P</i> = 0.003).
|
31178907 |
2019 |
|
rs5443
|
|
Craniosynostosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Unique to our study is the establishment of an association between CRS in this patient population and GNB3 SNP rs5443, a variation in an established G protein component downstream of bitterant receptor signal transduction.
|
31137020 |
2019 |
|
rs5443
|
|
Gastroschisis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs4961 (ADD1), rs5443 (GNB3), rs1042713, and rs1042714 (ADRB2) were significantly associated with gastroschisis.
|
29550988 |
2018 |
|
rs5443
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current meta-analysis suggested that the GNB3 C825T polymorphism may contribute to increased risk of cancer, especially of thyroid carcinoma.
|
25536621 |
2018 |
|
rs5443
|
|
Ataxia with vitamin E deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
No study has assessed the possible involvement of endothelial nitric oxide synthase (eNOS) T-786C and G894T and G-protein β3 subunit (GNB3) C825T polymorphisms with susceptibility to diabetic vasculogenic erectile dysfunction (VED) in North African subjects.
|
30101547 |
2018 |
|
rs5443
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
The current meta-analysis suggested that the GNB3 C825T polymorphism may contribute to increased risk of cancer, especially of thyroid carcinoma.
|
25536621 |
2018 |
|
rs5443
|
|
Bipolar II disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
At baseline, the GNB3 C825T polymorphisms were associated with the triglyceride level (P=0.032) in BP-II patients.
|
26856249 |
2017 |
|
rs5443
|
|
metabolic disturbance
|
|
0.010 |
GeneticVariation
|
BEFREE |
A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.
|
26856249 |
2017 |
|
rs5443
|
|
Recurrent depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of <i>BDNF</i>, rs5443 of <i>GNB3</i>, and rs1801133 of <i>MTHFR</i>; the <i>In/Del</i> polymorphism of <i>ACE</i>; and the <i>ε2</i> allele of <i>APOE</i> and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population.
|
27994504 |
2016 |
|
rs5443
|
|
Cardiomyopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.
|
26915373 |
2016 |
|
rs5443
|
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs5443 polymorphism did not moderate depressive symptom trajectories, regardless of the measure used.
|
24882179 |
2014 |
|
rs5443
|
|
Prehypertension
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study surveyed the frequencies of single nucleotide polymorphisms (SNPs) M235T AGT and C825T GNB3, and their association with insulin resistance, other biochemical markers and qualitative variables in subjects with high normal blood pressure and/or prehypertension in the Greek population.
|
24722130 |
2014 |
|
rs5443
|
|
Diarrhea
|
|
0.010 |
GeneticVariation
|
BEFREE |
The pooled results of four studies fail to show associations of GNB3 C825T polymorphism with subtypes of IBS (constipation-dominant type, diarrhea-dominant type and mixed type).
|
24876757 |
2014 |
|
rs5443
|
|
Vitelliform Macular Dystrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The 3-locus MDR model comprising FTO rs8050136C/A and GNB3 rs1129649T/C and rs5443C/T emerged as the best disease conferring model.
|
23691120 |
2013 |
|
rs5443
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using polymerase chain reaction and restriction fragment length polymorphism the allele frequency of the C825T polymorphism was investigated in 172 patients with prostate cancer.
|
22608746 |
2012 |
|
rs5443
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using polymerase chain reaction and restriction fragment length polymorphism the allele frequency of the C825T polymorphism was investigated in 172 patients with prostate cancer.
|
22608746 |
2012 |
|
rs5443
|
|
Breast Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the prevalence of the C825T polymorphism in the GNB3 gene in women with and without breast cancer and its possible association with clinical or pathological features of breast disease.
|
22034052 |
2012 |
|
rs5443
|
|
Adrenal incidentaloma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Aim of the study was to assess the prevalence of C825T GNB3 gene polymorphism in patients with adrenal incidentaloma (AI) as well as its relation to the metabolic syndrome (MS) and cortisol status.
|
21979884 |
2011 |
|
rs5443
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our aim in this study was to clarify any association of the GNB3 C825T polymorphism with gastric cancer risk in Japanese.
|
21198262 |
2010 |
|
rs5443
|
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the present observational study was to assess the value of the C825T polymorphism of the beta-3 subunit of G proteins (GNB3) as well as of variants in the SLC6A4 gene (5HTTLPR and STin2 VNTR) and DRD2 gene (TaqI A and NcoI) as predictive markers for consistency in headache response to triptans in migraine patients.
|
20488209 |
2010 |
|
rs5443
|
|
Endothelial dysfunction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of the study was to examine the association between the G protein β3 subunit C825T polymorphism, associated with cardiovascular risk factors like hypertension (HT) and obesity and microalbuminuria (MA), reflecting the endothelial dysfunction in the atherosclerotic process.
|
20577224 |
2010 |
|
rs5443
|
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gly972Arg and C825T polymorphisms are associated neither with PCOS nor with metabolic syndrome in the Slovak female population.
|
20170352 |
2010 |
|
rs5443
|
|
Extrahepatic Cholangiocarcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Prognostic assessment of three single-nucleotide polymorphisms (GNB3 825C>T, BCL2-938C>A, MCL1-386C>G) in extrahepatic cholangiocarcinoma.
|
19968497 |
2010 |
|
rs5443
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our aim in this study was to clarify any association of the GNB3 C825T polymorphism with gastric cancer risk in Japanese.
|
21198262 |
2010 |