|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate whether this variant is associated with hypertension or blood pressure in other human samples, we genotyped 447 young adult Oji-Cree for the GNB3 C825T variation.
|
9774364 |
1998 |
|
rs5443
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
Within this group we have also examined the inheritance of C825T alleles in a family study and found no evidence for excess transmission of the T allele to Type I diabetic offspring with nephropathy (T allele transmitted to 51% of nephropathy offspring, C allele transmitted to 49% of nephropathy offspring, p = 0.79).
|
9833937 |
1998 |
|
rs5443
|
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.030 |
GeneticVariation
|
BEFREE |
In conclusion we can find no evidence for the C825T polymorphism of the beta3 G-protein subunit as a major gene in the susceptibility to diabetic nephropathy in Type I diabetes.
|
9833937 |
1998 |
|
rs5443
|
|
Diabetic Nephropathy
|
|
0.020 |
GeneticVariation
|
BEFREE |
In conclusion we can find no evidence for the C825T polymorphism of the beta3 G-protein subunit as a major gene in the susceptibility to diabetic nephropathy in Type I diabetes.
|
9833937 |
1998 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism (C825T) in exon 10 of the gene encoding the beta 3 subunit of heterotrimeric G proteins (GN beta 3) has recently been described, and the T allele was found to be associated with late-onset hypertension.
|
10200987 |
1999 |
|
rs5443
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
Because hypertension is a known risk factor for the development of clinically manifest progressive renal disease, we examined the C825T polymorphism in older hemodialysis patients suffering from nondiabetic renal disease or type 2 diabetes with presumed diabetic nephropathy, respectively, and in older healthy controls.
|
10200987 |
1999 |
|
rs5443
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
Because hypertension is a known risk factor for the development of clinically manifest progressive renal disease, we examined the C825T polymorphism in older hemodialysis patients suffering from nondiabetic renal disease or type 2 diabetes with presumed diabetic nephropathy, respectively, and in older healthy controls.
|
10200987 |
1999 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The 825C/T polymorphism of the G-protein subunit beta3 is not related to hypertension.
|
10334807 |
1999 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the 825C/T polymorphism of the GNB3 gene did not contribute in any important way to the risk of essential hypertension or MI in these studies.
|
10334807 |
1999 |
|
rs5443
|
|
Myocardial Infarction
|
|
0.070 |
GeneticVariation
|
BEFREE |
We conclude that the 825C/T polymorphism of the GNB3 gene did not contribute in any important way to the risk of essential hypertension or MI in these studies.
|
10334807 |
1999 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity.
|
10477144 |
1999 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
BP values in young male whites increased significantly with increasing BMI values but were independent of the C825T polymorphism, suggesting that hypertension associated with the 825T allele could be a consequence of obesity.
|
10477144 |
1999 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
In 34 white patients with established mild to moderate essential hypertension (World Health Organization stage I or II, mean age 52 +/- 9 years) genotype analysis of GNB3 C825T polymorphism, insertion/deletion polymorphism of the ACE gene and 1166 A/C polymorphism of the AT1 receptor gene was performed.
|
10526907 |
1999 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent study has revealed that a novel variant (C825T) in exon 10 of the gene encoding the beta3 subunit of heterotrimetric G proteins (GNB3) is a genetic factor predisposing to hypertension in Caucasians.
|
10701813 |
2000 |
|
rs5443
|
|
Myocardial Infarction
|
|
0.070 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, 3 physiologically important candidate gene mutations (angiotensinogen A[-6], alpha-Adducin Gly460Trp, and G-Protein beta(3)-subunit C825T) were examined for their association with hypertension status in a sample of 904 African Americans from Jackson, Mississippi.
|
10856280 |
2000 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study provided evidence against the major impact of the GNB3 C825T polymorphism on the increased risk of the development of nephropathy or hypertension in type 2 diabetic patients.
|
10970984 |
2000 |
|
rs5443
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.050 |
GeneticVariation
|
BEFREE |
G-Protein beta(3) subunit C825T variant, nephropathy and hypertension in patients with type 2 (Non-insulin-dependent) diabetes mellitus.
|
10970984 |
2000 |
|
rs5443
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
The study provided evidence against the major impact of the GNB3 C825T polymorphism on the increased risk of the development of nephropathy or hypertension in type 2 diabetic patients.
|
10970984 |
2000 |
|
rs5443
|
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
G-protein beta(3)-subunit C825T genotype and nephropathy in diabetes mellitus.
|
10978395 |
2000 |
|
rs5443
|
|
Kidney Diseases
|
|
0.040 |
GeneticVariation
|
BEFREE |
G-protein beta(3)-subunit C825T genotype and nephropathy in diabetes mellitus.
|
10978395 |
2000 |
|
rs5443
|
|
Essential Hypertension
|
|
0.100 |
GeneticVariation
|
BEFREE |
GNB3 825C-->T is not associated with the phenotype of hypertensive crisis in patients suffering from essential hypertension.
|
11008983 |
2000 |