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rs5443
|
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
While the platelet glycoprotein IIb/IIIa is involved in the pathogenesis of acute coronary syndromes whereas most platelet activating stimuli act via G Protein coupled receptors we investigated whether the 825C>T polymorphism of the gene GNB3 encoding the G protein beta3 subunit together with the platelet glycoprotein (GP) IIIa Pl(A) polymorphism are predictive of platelet aggregability on stimulation with various agonists acting via GPCRs.
|
12818251 |
2003 |
|
rs5443
|
|
Adenoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Different genotype distribution of the GNB3 C825T polymorphism of the G protein beta3 subunit in adenomas and differentiated thyroid carcinomas of follicular cell origin.
|
16178055 |
2005 |
|
rs5443
|
|
Adrenal incidentaloma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Aim of the study was to assess the prevalence of C825T GNB3 gene polymorphism in patients with adrenal incidentaloma (AI) as well as its relation to the metabolic syndrome (MS) and cortisol status.
|
21979884 |
2011 |
|
rs5443
|
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The GNB3 C825T polymorphism and depression among subjects with alcohol dependence.
|
16897596 |
2007 |
|
rs5443
|
|
Angina Pectoris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Effects of lifestyle modification on the progression of coronary atherosclerosis, autonomic function, and angina--the role of GNB3 C825T polymorphism.
|
16569552 |
2006 |
|
rs5443
|
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
On these grounds, we studied the C825T polymorphism in relation to atherosclerosis-related phenotypes in a large Japanese population.
|
15033462 |
2004 |
|
rs5443
|
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI).
|
18551043 |
2008 |
|
rs5443
|
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The GNB3 825C>T genotype was measured in a sample of 14,716 African Americans (AAs) and whites from the Atherosclerosis Risk in Communities (ARIC) study, and logistic regression was used to test for genetic effects and gene-environment interactions.
|
17299380 |
2007 |
|
rs5443
|
|
Arteriosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
For this reason, we examined the association between the alpha-adducin (ADD1) G460W and G-protein beta3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study.
|
12052841 |
2002 |
|
rs5443
|
|
Ataxia with vitamin E deficiency
|
|
0.010 |
GeneticVariation
|
BEFREE |
No study has assessed the possible involvement of endothelial nitric oxide synthase (eNOS) T-786C and G894T and G-protein β3 subunit (GNB3) C825T polymorphisms with susceptibility to diabetic vasculogenic erectile dysfunction (VED) in North African subjects.
|
30101547 |
2018 |
|
rs5443
|
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The GNB3 825C>T genotype was measured in a sample of 14,716 African Americans (AAs) and whites from the Atherosclerosis Risk in Communities (ARIC) study, and logistic regression was used to test for genetic effects and gene-environment interactions.
|
17299380 |
2007 |
|
rs5443
|
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
For this reason, we examined the association between the alpha-adducin (ADD1) G460W and G-protein beta3 subunit (GNB3) 825C>T polymorphisms and the prevalence of peripheral arterial disease (PAD) and incidence of coronary heart disease (CHD) in non-Hispanic whites from the Atherosclerosis Risk in Communities (ARIC) Study.
|
12052841 |
2002 |
|
rs5443
|
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The GNB3 C825T polymorphism has been shown to affect lipid parameters, atherosclerosis progression, and incidence of myocardial infarction (MI).
|
18551043 |
2008 |
|
rs5443
|
|
Atherosclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
On these grounds, we studied the C825T polymorphism in relation to atherosclerosis-related phenotypes in a large Japanese population.
|
15033462 |
2004 |
|
rs5443
|
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
C825T polymorphism of the G-protein beta3 subunit gene and atrial fibrillation: association of the TT genotype with a reduced risk for atrial fibrillation.
|
15389246 |
2004 |
|
rs5443
|
|
Bipolar II disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
At baseline, the GNB3 C825T polymorphisms were associated with the triglyceride level (P=0.032) in BP-II patients.
|
26856249 |
2017 |
|
rs5443
|
|
Bladder Neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer.
|
16133558 |
2005 |
|
rs5443
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our data indicate that the C825T polymorphism in the GNB3 gene has no relationship to the risk for breast cancer or the characteristics of the disease.
|
22034052 |
2012 |
|
rs5443
|
|
Breast Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
We conclude that the GNB3 825C>T polymorphism does not appear to be associated with breast cancer risk, but may influence development of metastasis in low-grade tumors.
|
15019160 |
2004 |
|
rs5443
|
|
Breast Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the prevalence of the C825T polymorphism in the GNB3 gene in women with and without breast cancer and its possible association with clinical or pathological features of breast disease.
|
22034052 |
2012 |
|
rs5443
|
|
Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To elucidate a possible role in the development and course of thyroid tumours of follicular cell origin, C825T polymorphism genotypes and allele frequencies were investigated in a series of adenomas and differentiated carcinomas.
|
16178055 |
2005 |
|
rs5443
|
|
Carcinoma of bladder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer.
|
16133558 |
2005 |
|
rs5443
|
|
Cardiac Arrhythmia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results from this pilot study suggest that the C825T polymorphism may have a modifying effect on the propensity towards life-threatening arrhythmias.
|
16783490 |
2006 |
|
rs5443
|
|
Cardiomyopathies
|
|
0.010 |
GeneticVariation
|
BEFREE |
GNB3 C825T Polymorphism and Myocardial Recovery in Peripartum Cardiomyopathy: Results of the Multicenter Investigations of Pregnancy-Associated Cardiomyopathy Study.
|
26915373 |
2016 |
|
rs5443
|
|
Cardiovascular Diseases
|
|
0.050 |
GeneticVariation
|
BEFREE |
Several recent studies showed that C825T polymorphism is related to cardiovascular diseases in normal population.
|
28067546 |
2017 |