|
rs5443
|
|
Vesico-Ureteral Reflux
|
|
0.020 |
GeneticVariation
|
BEFREE |
(2) TT genotype polymorphism rs5443 GNB3 gene may be a protective factor for the improved renal function in patients with primary vesicoureteral reflux in patients with genotype CC or CT.
|
27988909 |
2017 |
|
rs5443
|
|
Gastroesophageal reflux disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
GERD is associated with GNB3 C825T.The results for GERD subgroups support the hypothesis that enhanced perception of reflux events, as a consequence of the increased signal transduction upon GPCR activation associated with the 825T allele, underlies this association.
|
19174793 |
2009 |
|
rs5443
|
|
Hunger
|
|
0.010 |
GeneticVariation
|
BEFREE |
Hunger and mood during extended fasting are dependent on the GNB3 C825T polymorphism.
|
19420911 |
2009 |
|
rs5443
|
|
Coronary Artery Disease
|
|
0.040 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Coronary Arteriosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Myocardial Infarction
|
|
0.070 |
GeneticVariation
|
BEFREE |
C825T polymorphism in the G protein beta3 subunit gene (GNB3) has been associated with arterial hypertension, coronary artery disease and myocardial infarction.
|
10704626 |
2000 |
|
rs5443
|
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
C825T polymorphism of the G-protein beta3 subunit gene and atrial fibrillation: association of the TT genotype with a reduced risk for atrial fibrillation.
|
15389246 |
2004 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A C825T polymorphism of a gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder.
|
12075862 |
2002 |
|
rs5443
|
|
Depressive disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
A C825T polymorphism of a gene encoding the beta3 subunit of heterotrimeric G proteins (GNB3) was reported to be associated with several pathological conditions, such as hypertension and depressive disorder.
|
12075862 |
2002 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A C825T polymorphism was identified in the gene encoding the G-protein beta3 subunit (GNB3), and an association of the T-allele with hypertension was demonstrated in several studies.
|
15037876 |
2004 |
|
rs5443
|
|
Depressive disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443).
|
28499211 |
2017 |
|
rs5443
|
|
Mental Depression
|
|
0.050 |
GeneticVariation
|
BEFREE |
A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443).
|
28499211 |
2017 |
|
rs5443
|
|
Depressed mood
|
|
0.050 |
GeneticVariation
|
BEFREE |
A case-control association study (225 healthy adults and 188 outpatients with depression) was performed to establish Risk-Combined Genotype (RCG) of the studied variants (OXTR rs53576 and the functional Gβ3 subunit rs5443).
|
28499211 |
2017 |
|
rs5443
|
|
Diabetes Mellitus
|
|
0.040 |
GeneticVariation
|
BEFREE |
A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI.
|
18656447 |
2008 |
|
rs5443
|
|
Diabetes
|
|
0.020 |
GeneticVariation
|
BEFREE |
A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI.
|
18656447 |
2008 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common C825T polymorphism in the gene GNB3, which encodes the beta 3 subunit of heterotrimeric G proteins, was identified in cell lines from patients with hypertension.
|
15660499 |
2005 |
|
rs5443
|
|
Metabolic Syndrome X
|
|
0.060 |
GeneticVariation
|
BEFREE |
A common 825C>T polymorphism in exon 10 of the gene for the beta-3 subunit of heterotrimeric G-proteins, GNB3, has been associated in some studies with traits of the metabolic syndrome as well as coronary artery disease (CAD), but these associations were refuted by other studies.
|
16908025 |
2007 |
|
rs5443
|
|
metabolic disturbance
|
|
0.010 |
GeneticVariation
|
BEFREE |
A longitudinal study of the association between the GNB3 C825T polymorphism and metabolic disturbance in bipolar II patients treated with valproate.
|
26856249 |
2017 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism (C825T) in exon 10 of the gene encoding the beta 3 subunit of heterotrimeric G proteins (GN beta 3) has recently been described, and the T allele was found to be associated with late-onset hypertension.
|
10200987 |
1999 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism (C825T) in the gene encoding the G protein beta3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations.
|
12109775 |
2002 |
|
rs5443
|
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
A polymorphism (C825T) in the gene encoding the G protein beta3 subunit (GNB3) has recently been associated with hypertension and obesity in several populations.
|
12109775 |
2002 |
|
rs5443
|
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent study has revealed that a novel variant (C825T) in exon 10 of the gene encoding the beta3 subunit of heterotrimetric G proteins (GNB3) is a genetic factor predisposing to hypertension in Caucasians.
|
10701813 |
2000 |
|
rs5443
|
|
Heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
A total of 350 subjects enrolled in the genetic substudy (GRAHF [Genetic Risk Assessment of Heart Failure in African Americans]) were genotyped for the C825T polymorphism.
|
25306451 |
2014 |
|
rs5443
|
|
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
A total of 350 subjects enrolled in the genetic substudy (GRAHF [Genetic Risk Assessment of Heart Failure in African Americans]) were genotyped for the C825T polymorphism.
|
25306451 |
2014 |