|
rs1245560
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Fine mapping confirmed the association of rs1245560 with bronchopulmonary dysplasia in both white and African populations with adjusted odds ratios of 2.96 (95% confidence interval [CI], 1.37-6.40) and 4.87 (95% CI, 1.88-12.63), respectively.
|
21836138 |
2011 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.
|
25874530 |
2015 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results.
|
16152572 |
2005 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The association between Val66Met polymorphism and BPD, treatment response to mood stabilizers, was estimated.
|
22548711 |
2012 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole.
|
18242852 |
2008 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD.
|
12524161 |
2003 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Overall, there was no significant difference in allelic distribution of Val66Met polymorphism between patients and controls with a pooled OR = 1.03 (95% CI 0.98, 1.08) although there was a trend towards association between Val66Met polymorphism and BPD in Caucasians with an OR of 1.08 (95% CI 1.00, 1.16).
|
25539739 |
2014 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results.
|
16152572 |
2005 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD.
|
12524161 |
2003 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Overall, there was no significant difference in allelic distribution of Val66Met polymorphism between patients and controls with a pooled OR = 1.03 (95% CI 0.98, 1.08) although there was a trend towards association between Val66Met polymorphism and BPD in Caucasians with an OR of 1.08 (95% CI 1.00, 1.16).
|
25539739 |
2014 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole.
|
18242852 |
2008 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The association between Val66Met polymorphism and BPD, treatment response to mood stabilizers, was estimated.
|
22548711 |
2012 |
|
rs759834365
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.
|
25874530 |
2015 |
|
rs10994336
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found no association in the ANK3 markers, but the rs10994336 variant was nominally associated with non-psychotic BPD (P = 0.046).
|
21767209 |
2011 |
|
rs10994336
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Following stratification by ethnicity, variants of the ANK3 gene (rs1938516 and rs10994336) were found to be associated with BPD in Malays (P-value=0.001 and 0.006, respectively).
|
24914473 |
2014 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MTHFR C677T was significantly associated with all of the combined psychiatric disorders (SZ, BPD and UDD); random effects odds ratio (OR)=1.26 for TT versus CC genotype carriers; confidence interval (CI) 1.09-1.46); meta-regression did not suggest moderating effects of psychiatric diagnosis, sex, ethnic group or year of publication.
|
21185933 |
2011 |
|
rs1217691063
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Meta-analysis showed that MTHFR C677T was significantly associated with SZ, the highest OR was found for the recessive model (for TT vs. CT + CC: OR = 1.34, 95% CI: 1.18-1.53); a marginal association of MTHFR C677T with increased risk of BPD has also been found for the recessive model (OR = 1.26, 95% CI: 1.00-1.59).
|
24938371 |
2015 |
|
rs2070744
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that TC+CC rs2070744 eNOS and GT+TT rs1799983 eNOS polymorphisms are independent predictors of an increased risk of developing BPD.
|
26172140 |
2015 |
|
rs2070744
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We could replicate and extend previous findings showing altered NOx (-) levels in BPD and an influence of NOS3 rs2070744 on NOS3 expression and NOx (-) concentration.
|
25320160 |
2015 |
|
rs2230912
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After correction for multiple testing, the association between rs2230912 and HADS-depression score remained significant in the BPD group (p<0.006); this genetic effect explained 9% of the variance (partial η(2)=0.09).
|
23602648 |
2013 |
|
rs2230912
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here we present a case-control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression.
|
18543274 |
2009 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Subgroup analysis indicated a significant association with SZ existed in Asian populations, not among the white populations and no significant association was detected between the MTHFR A1298C and BPD in all groups.
|
24938371 |
2015 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although MTHFR A1298C was not significantly associated with the combination of major psychiatric disorders, nor with SZ, there was evidence for diagnostic moderation indicating a significant association with BPD (random effects OR=2.03 for AA versus CC genotype carriers, CI: 1.07-3.86).
|
21185933 |
2011 |