|
rs3800373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs3800373 FKBP5 may increase the risk of developing predominantly depressed BPD, probably through the creation of an enhancer consensus sequence in the 3'UTR of the gene, thus potentially increasing its expression.
|
31071710 |
2019 |
|
rs1440306
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
|
23897914 |
2013 |
|
rs1440306
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
|
23897914 |
2013 |
|
rs556493
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
|
23897914 |
2013 |
|
rs556493
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
|
23897914 |
2013 |
|
rs72791417
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
|
23897914 |
2013 |
|
rs72791417
|
|
A |
0.800 |
GeneticVariation |
GWASDB |
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
|
23897914 |
2013 |
|
rs3093059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of other SNPs in the CRP region, including rs3093059, had nominal associations with BPD.
|
28839172 |
2017 |
|
rs6313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ).
|
24962835 |
2014 |
|
rs5744168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A TLR5 (g.1174C > T) variant that encodes a stop codon (R392X) is associated with bronchopulmonary dysplasia.
|
22058078 |
2012 |
|
rs2664352
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for birth weight and ethnic origin, the TT genotype of MMP16 C/T (rs2664352) and the GG genotype of MMP16 A/G (rs2664349) were found to protect from BPD.
|
18784838 |
2008 |
|
rs2664349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjustment for birth weight and ethnic origin, the TT genotype of MMP16 C/T (rs2664352) and the GG genotype of MMP16 A/G (rs2664349) were found to protect from BPD.
|
18784838 |
2008 |
|
rs11199993
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting the multiple tests by permutation, one SNP (rs11199993), and a haplotype including this SNP, was found to be significantly associated with BPD.
|
22404656 |
2012 |
|
rs2230912
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After correction for multiple testing, the association between rs2230912 and HADS-depression score remained significant in the BPD group (p<0.006); this genetic effect explained 9% of the variance (partial η(2)=0.09).
|
23602648 |
2013 |
|
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although MTHFR A1298C was not significantly associated with the combination of major psychiatric disorders, nor with SZ, there was evidence for diagnostic moderation indicating a significant association with BPD (random effects OR=2.03 for AA versus CC genotype carriers, CI: 1.07-3.86).
|
21185933 |
2011 |
|
rs2709370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories.
|
29158582 |
2018 |
|
rs7975
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility.
|
22374552 |
2012 |
|
rs1800450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An association was found between two SNPs and the development of bronchopulmonary dysplasia (BPD), defined as persistent oxygen requirement at 36 weeks postmenstrual age, adjusting for covariates GA, grade of respiratory distress syndrome and days on mechanical ventilation (rs1800450 (exon 1 at codon 54, B variant): odds ratio dominant model (OR)=3.59, 95% confidence interval (CI)=1.62-7.98; rs7096206 (-221, X variant): OR=2.40, 95% CI=1.16-4.96).
|
17898783 |
2007 |
|
rs7096206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An association was found between two SNPs and the development of bronchopulmonary dysplasia (BPD), defined as persistent oxygen requirement at 36 weeks postmenstrual age, adjusting for covariates GA, grade of respiratory distress syndrome and days on mechanical ventilation (rs1800450 (exon 1 at codon 54, B variant): odds ratio dominant model (OR)=3.59, 95% confidence interval (CI)=1.62-7.98; rs7096206 (-221, X variant): OR=2.40, 95% CI=1.16-4.96).
|
17898783 |
2007 |
|
rs372271081
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Ancestry and genetic associations with bronchopulmonary dysplasia in preterm infants.
|
30113228 |
2018 |
|
rs2781666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Arginase I SNP (rs2781666) may be associated with protection against pulmonary hypertension in preterm neonates with BPD.
|
24919409 |
2014 |
|
rs174576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans.
|
30531795 |
2018 |
|
rs78089757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans.
|
30531795 |
2018 |
|
rs187269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease-control differences were significantly correlated with SNP rs187269 in BPD males for both beta(2S1) and beta(2S2) expressions, and significantly correlated with SNPs rs2546620 and rs187269 in SCZ males for beta(2S2) expression.
|
19763268 |
2009 |
|
rs2546620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease-control differences were significantly correlated with SNP rs187269 in BPD males for both beta(2S1) and beta(2S2) expressions, and significantly correlated with SNPs rs2546620 and rs187269 in SCZ males for beta(2S2) expression.
|
19763268 |
2009 |