|
rs11265269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, SNP rs11265269 was identified as a risk factor of BPD (OR 1.8, p = 5.3 × 10<sup>-5</sup>), independently of the robust antenatal risk factors.
|
28839172 |
2017 |
|
rs2709370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories.
|
29158582 |
2018 |
|
rs6746896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We showed a positive association between LMAN2L (rs6746896) and risk of both BPD and SZ in a pooled population (P-value=0.001 and 0.009, respectively).
|
24914473 |
2014 |
|
rs778293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results provide first evidence for the single nucleotide polymorphism rs778293 in G72 as a potential candidate in altering risk for BPD in the Chinese Han population.
|
19339914 |
2009 |
|
rs78089757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans.
|
30531795 |
2018 |
|
rs17135889
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant correlation existed between the rs17135889 genotypes (AG/GG) and any clinical characteristic (e.g., oxygen supplementation duration and hospitalization, requirement for ventilation, bronchopulmonary dysplasia complications, and mortality rate).
|
26522252 |
2016 |
|
rs371131106
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Indeed, carrier states of genetic variants of cytokines (IFNgamma T+874A), adhesion molecules (L-selectin-Pro213Ser), elements of renin-angiotensin system (ACE-I/D), antioxidant enzymes (GST-P1 Val105Ile), and surfactant proteins (SPA1, SPB intron 4) has been identified as risk factors to BPD.
|
17726703 |
2007 |
|
rs4351
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also observed the A allele of rs4351 in the angiotensin-converting enzyme (ACE) gene was overtransmitted from parents to VPTB offspring with BPD (P=9.8 × 10(-3)).
|
21960125 |
2012 |
|
rs1610037
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping of seven single nucleotide polymorphisms (rs1893154; rs2846811; rs8192595; rs2856966; rs928978; rs2231187; rs1610037) was performed in BPD patients (n=570) and healthy controls (n=710).
|
18349695 |
2008 |
|
rs35320474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed a significant correlation between rs35320474-C/T and T/T genotypes and apnoea and BPD development.
|
22462821 |
2012 |
|
rs1010419
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.
|
21836138 |
2011 |
|
rs2701405
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.
|
21836138 |
2011 |
|
rs10152333
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia.
|
21836138 |
2011 |
|
rs10994336
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found no association in the ANK3 markers, but the rs10994336 variant was nominally associated with non-psychotic BPD (P = 0.046).
|
21767209 |
2011 |
|
rs10994336
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Following stratification by ethnicity, variants of the ANK3 gene (rs1938516 and rs10994336) were found to be associated with BPD in Malays (P-value=0.001 and 0.006, respectively).
|
24914473 |
2014 |
|
rs2781666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Arginase I SNP (rs2781666) may be associated with protection against pulmonary hypertension in preterm neonates with BPD.
|
24919409 |
2014 |
|
rs165599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These data suggest that COMT genetic variation at SNP rs165599 is associated with BPD I and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.
|
17547583 |
2007 |
|
rs956572
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we examined the effects of the Bcl-2 gene single nucleotide polymorphism (SNP) rs956572 on intracellular Ca(2+) dynamics in patients with BPD.
|
21167476 |
2011 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The positive association of BNDF Val66Met with high BMI values replicates previous findings in patients with SCZ and indicates the BDNF Val66Met genotype as a potential risk factor for obesity and insulin resistance measures in patients with BPD receiving antipsychotics as well.
|
25874530 |
2015 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results.
|
16152572 |
2005 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The association between Val66Met polymorphism and BPD, treatment response to mood stabilizers, was estimated.
|
22548711 |
2012 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole.
|
18242852 |
2008 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD.
|
12524161 |
2003 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Previous studies have suggested that the Val66Met (also known as rs6265 or G196A) variant of BDNF is associated with bipolar disorder (BPD), but the results have been inconclusive.
|
19330778 |
2010 |
|
rs6265
|
|
|
0.070 |
GeneticVariation |
BEFREE |
Overall, there was no significant difference in allelic distribution of Val66Met polymorphism between patients and controls with a pooled OR = 1.03 (95% CI 0.98, 1.08) although there was a trend towards association between Val66Met polymorphism and BPD in Caucasians with an OR of 1.08 (95% CI 1.00, 1.16).
|
25539739 |
2014 |