|
rs1042606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our BPD cohort, 32% (n = 61) had PH.Of the DUSP SNPs evaluated, DUSP1 SNP rs322351 was less common, and DUSP5 SNPs rs1042606 and rs3793892 were more common in cases than in controls.
|
31330530 |
2020 |
|
rs2066713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs25531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs322351
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our BPD cohort, 32% (n = 61) had PH.Of the DUSP SNPs evaluated, DUSP1 SNP rs322351 was less common, and DUSP5 SNPs rs1042606 and rs3793892 were more common in cases than in controls.
|
31330530 |
2020 |
|
rs3793892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our BPD cohort, 32% (n = 61) had PH.Of the DUSP SNPs evaluated, DUSP1 SNP rs322351 was less common, and DUSP5 SNPs rs1042606 and rs3793892 were more common in cases than in controls.
|
31330530 |
2020 |
|
rs4251417
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs6354
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs7224199
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p<sub>d</sub> = 9.25 × 10<sup>-03</sup>, p<sub>r</sub> = 7.24 × 10<sup>-03</sup>; rs2066713 p<sub>d</sub> = 6.35 × 10<sup>-08</sup>; rs25531 p<sub>d</sub> = 2.95 × 10<sup>-02</sup>; rs4251417 p<sub>d</sub> = 2.46 × 10<sup>-03</sup>), and ALZ (rs6354 p<sub>r</sub> = 1.22 × 10<sup>-02</sup>; rs7224199 p<sub>d</sub> = 1.00 × 10<sup>-08</sup>, p<sub>r</sub> = 2.65 × 10<sup>-02</sup>) cohorts.
|
31595439 |
2020 |
|
rs3800373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs3800373 FKBP5 may increase the risk of developing predominantly depressed BPD, probably through the creation of an enhancer consensus sequence in the 3'UTR of the gene, thus potentially increasing its expression.
|
31071710 |
2019 |
|
rs61749465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The evidence for association between rs61749465A>G and psychosis in both BPD and SCZ warrants further replication.
|
30859703 |
2019 |
|
rs61749465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report evidence for association of rs61749465A>G with BPD</span> (p = 0.0009). rs61749465 is located in the N-terminal of the BRCT1 domain of MCPH1.
|
30859703 |
2019 |
|
rs9371601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data confirms the association between rs9371601 and BPD, but the underlying biological mechanism remains to be fully elucidated in further studies.
|
31236099 |
2019 |
|
rs174576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans.
|
30531795 |
2018 |
|
rs2709370
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the associations of both CREB1 SNPs with each illness were not replicated in the new cohorts (BPD analysis in 871 cases and 1089 controls (rs2709370, P=0.0611; rs6785, P=0.0544); SCZ analysis in 1273 cases and 1072 controls (rs2709370, P=0.230; rs6785, P=0.661); and MDD analysis in 129 cases and 100 controls (rs2709370, P=0.114; rs6785, P=0.188)), an overall meta-analysis of all included samples suggested that both SNPs were significantly associated with increased risk of BPD (11 105 cases and 51 331 controls; rs2709370, P=2.33 × 10<sup>-4</sup>; rs6785, P=6.33 × 10<sup>-5</sup>), SCZ (34 913 cases and 44 528 controls; rs2709370, P=3.96 × 10<sup>-5</sup>; rs6785, P=2.44 × 10<sup>-5</sup>) and MDD (9369 cases and 9619 controls; rs2709370, P=0.0144; rs6785, P=0.0314), with the same direction of allelic effects across diagnostic categories.
|
29158582 |
2018 |
|
rs361525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TNF rs361525 polymorphism could influence BPD risk among Han Chinese newborns.
|
29136357 |
2018 |
|
rs6785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample).
|
29158582 |
2018 |
|
rs78089757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Aside from replicating previously reported BPD risk SNPs, we herein also report several intriguing findings: (1) the SNP rs174576 was associated with BPD in our Chinese sample and in the overall global meta-analysis, and was significantly correlated with FADS1 mRNA in diverse public RNA-seq datasets as well as our in house collected Chinese amygdala samples; (2) two (partially) independent SNPs in MAD1L1 were both significantly associated with BPD in our Chinese sample, which was also supported by haplotype analysis; (3) a rare SNP rs78089757 in 10q26.13 region was a genome-wide significant variant for BPD in East Asians, and this SNP was near monomorphic in Europeans.
|
30531795 |
2018 |
|
rs11265269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, SNP rs11265269 was identified as a risk factor of BPD (OR 1.8, p = 5.3 × 10<sup>-5</sup>), independently of the robust antenatal risk factors.
|
28839172 |
2017 |
|
rs1344706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis showed that rs1344706 and rs7597593 were both associated with major mood disorders as well as diagnosis of either BPD or MDD, although neither of the analyses achieved a genome-wide level of statistical significance.
|
27784192 |
2017 |
|
rs2251219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, the CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous BPD genome-wide association studies (GWAS), but CHDH is lying outside of the core GWAS linkage disequilibrium (LD) region, and our studied SNP rs9836592 is ∼1.2 Mb 3' downstream of the previous GWAS loci (e.g., rs2251219) with no LD between them; thus, the association observed here is unlikely a reflection of previous GWAS signals.
|
27562178 |
2017 |
|
rs3093059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of other SNPs in the CRP region, including rs3093059, had nominal associations with BPD.
|
28839172 |
2017 |
|
rs7597593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis showed that rs1344706 and rs7597593 were both associated with major mood disorders as well as diagnosis of either BPD or MDD, although neither of the analyses achieved a genome-wide level of statistical significance.
|
27784192 |
2017 |
|
rs9836592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Intriguingly, the CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous BPD genome-wide association studies (GWAS), but CHDH is lying outside of the core GWAS linkage disequilibrium (LD) region, and our studied SNP rs9836592 is ∼1.2 Mb 3' downstream of the previous GWAS loci (e.g., rs2251219) with no LD between them; thus, the association observed here is unlikely a reflection of previous GWAS signals.
|
27562178 |
2017 |
|
rs17135889
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant correlation existed between the rs17135889 genotypes (AG/GG) and any clinical characteristic (e.g., oxygen supplementation duration and hospitalization, requirement for ventilation, bronchopulmonary dysplasia complications, and mortality rate).
|
26522252 |
2016 |
|
rs480414
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the DDAH1 rs480414 may be a useful biomarker in developing predictive models for PH in patients with BPD.
|
26663142 |
2016 |