|
rs5743618
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings revealed that TLR1 rs5743551 and rs5743618 polymorphisms affected the risk of PTB in an Iranian population sample.
|
27998389 |
2016 |
|
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study demonstrates that T597C polymorphism of TLR2 is a risk factor for susceptibility to PTB rather than to TBM in a sample of Chinese adult population.
|
26722451 |
2015 |
|
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our data suggest that 597T/C polymorphism, but not Arg677Trp polymorphism, of the TLR-2 gene is a risk factor for susceptibility to PTB in a sample of Iranian population.
|
23830055 |
2014 |
|
rs2476601
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study is the first to investigate the association between pulmonary TB and the PTPN22 1858C/T polymorphism in the Brazilian Amazon.
|
23499775 |
2013 |
|
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
TLR2 2258G allele may provide protective effects against PTB susceptibility, particularly among Asians, whereas TLR2 T597C polymorphism might not be associated with PTB susceptibility.
|
24124467 |
2013 |
|
rs5743618
|
|
|
0.040 |
GeneticVariation |
BEFREE |
T1805G, a functional TLR1 single nucleotide polymorphism (SNP), has been associated with susceptibility to pulmonary tuberculosis (PTB), but contradictory results among different populations have been reported.
|
23575331 |
2013 |
|
rs2476601
|
|
|
0.040 |
GeneticVariation |
BEFREE |
R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran.
|
22614276 |
2012 |
|
rs5743618
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
|
rs5743618
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
|
rs2476601
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The purpose of this study was to investigate the role of two functional missense single nucleotide polymorphisms (SNPs) of the PTPN22 gene region (R620W and R263Q) in the susceptibility to TB in the Moroccan population.
|
19563523 |
2009 |
|
rs1800450
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, the other genetic models of rs1800450 (A>B), rs7096206 (Y>X), and rs11003125 (H>L) MBL2 gene polymorphisms did not divulge any association with PTB susceptibility.
|
30666135 |
2019 |
|
rs1800450
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The overall results indicated that the MBL-2 rs1800450 (54 A/B) and rs5030737 (52 A/D) polymorphisms were risk factors for PTB, but the MBL-2 rs1800451 (57 A/C) and rs7095891 (+4 P/Q) polymorphisms as protective factors against PTB.
|
30999018 |
2019 |
|
rs1800451
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The current meta-analysis concludes that rs1800451 (A>C) and rs5030737 (A>D) polymorphisms of MBL2 gene play a significant role in PTB susceptibility.
|
30666135 |
2019 |
|
rs1800451
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The overall results indicated that the MBL-2 rs1800450 (54 A/B) and rs5030737 (52 A/D) polymorphisms were risk factors for PTB, but the MBL-2 rs1800451 (57 A/C) and rs7095891 (+4 P/Q) polymorphisms as protective factors against PTB.
|
30999018 |
2019 |
|
rs3764880
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In summary, we show an association of SNP TLR8 rs3764880 with PTB in the Moldavian male population, providing support to previous studies conducted on other populations.
|
30529560 |
2019 |
|
rs1800872
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found correlations between one SNP in IL6 (rs2069837 <i>p</i> = 6.63E-11), seven SNPs in <i>IL10</i> (rs1554286 <i>p</i> = 6.87E-20, rs1518111 <i>p</i> = 6.11E-11, rs3021094 <i>p</i> = 6.75E-29, rs3790622 <i>p</i> = 2.40E-06, rs3024490 <i>p</i> = 6.73E-11, rs1800872 <i>p</i> = 6.18E-11, rs1800871 <i>p</i> = 6.73E-11) and incidences of PTB.
|
29662655 |
2018 |
|
rs187084
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The G allele of TLR9 SNP rs187084 was found to increase the risk of PTB (G vs A, P = 0.01, OR = 1.48, 95% CI = 1.10-2.00), the significance was also observed under dominant genetic models.
|
30424735 |
2018 |
|
rs3764880
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The AA genotype of rs3764880 SNP was found to increase the risk of PTB among females with an OR of 4.81 (1.11-20.85).
|
30424735 |
2018 |
|
rs1800629
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The <i>TNF-α</i> -238 A allele appeared a protective effect against STB, whereas the <i>SP110</i> SNPs (rs722555 and rs1135791) and <i>TNF-α</i> -308G>A (rs1800629) showed no association with susceptibility to PTB and STB patients in southern China.
|
29430075 |
2017 |
|
rs1800629
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility.
|
26840977 |
2016 |
|
rs1800872
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the association between previously reported SNPs IL2-330 T>G (rs2069762); IL4-590 C>T (rs2243250); IL6-174 G>C (rs1800795); IL10-592 A>C (rs1800872); IL10-1082 G>A (rs1800896); IL17A -692 C>T (rs8193036); IL17A -197 G>A (rs2275913); TNF -238 G>A (rs361525); TNF -308 G>A (rs1800629) and IFNG +874 T>A (rs2430561) and pulmonary TB (PTB) susceptibility.
|
26840977 |
2016 |
|
rs187084
|
|
|
0.030 |
GeneticVariation |
BEFREE |
BACKGROUND Findings regarding the association of the single-nucleotide polymorphisms (SNPs) rs4986790 and rs4986791 in Toll-like receptor 4 and rs187084, rs574386, and rs352139 in Toll-like receptor 9 (TLR9) with pulmonary tuberculosis (PTB) susceptibility are inconsistent.
|
25889916 |
2015 |
|
rs4986791
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, for TLR4 rs4986791, a significant increased PTB risk was found in Africans, and for TLR9 rs352139 a significant increased PTB risk was found in Asians after subgroup analysis by ethnicity, although the enrolled studies were limited.
|
25889916 |
2015 |
|
rs1800450
|
|
|
0.030 |
GeneticVariation |
BEFREE |
X/Y (rs7096206) and A/B (rs1800450) were genotyped in 765 new patients with active pulmonary TB without HIV infection and 556 controls in Hanoi, Viet Nam.
|
24952212 |
2014 |
|
rs187084
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Collectively, these data suggest that the minor "C" allele at rs187084 locus may be associated with susceptibility to PTB, which may explain the relatively lower PTB rates observed in Baiga tribe members.
|
25248338 |
2014 |