Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2069845
rs2069845
IL6
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.010 GeneticVariation BEFREE In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation. 30269203

2018

dbSNP: rs1800795
rs1800795
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.010 GeneticVariation BEFREE In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation. 30269203

2018

dbSNP: rs1800796
rs1800796
CUI: C0085693
Disease: Acute appendicitis NOS (disorder)
Acute appendicitis NOS (disorder)
0.010 GeneticVariation BEFREE With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA. 26714766

2015

dbSNP: rs1800796
rs1800796
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.010 GeneticVariation BEFREE the results suggest that IL-6 -572 G>C (rs1800796) polymorphism could be involved in the risk of developing ACS in Mexican individuals. 20939703

2010

dbSNP: rs1800795
rs1800795
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome
0.010 GeneticVariation BEFREE In the present study we investigated whether variants at -1082G→A (rs1800896) and -592C→A (rs1800872) of interleukin-10 (IL-10), -1188A→C (rs3212227) of IL-12 p40, -308G→A of tumor necrosis factor-α (TNF-α) (rs1800629), -174G→C of IL-6 (rs1800795) and +874A→T of interferon-γ (IFN-γ) genes (rs2430561) are associated with ACS. 22372709

2012

dbSNP: rs1800796
rs1800796
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome
0.010 GeneticVariation BEFREE The interleukin 6 -572 G>C (rs1800796) polymorphism is associated with the risk of developing acute coronary syndrome. 20939703

2010

dbSNP: rs1800795
rs1800795
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.020 GeneticVariation BEFREE Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models. 22282500

2012

dbSNP: rs1800795
rs1800795
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.020 GeneticVariation BEFREE Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant. 29513361

2018

dbSNP: rs1800797
rs1800797
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease
0.010 GeneticVariation BEFREE Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD. 25774595

2015

dbSNP: rs1800796
rs1800796
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.010 GeneticVariation BEFREE However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk. 24072654

2013

dbSNP: rs1800795
rs1800795
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis
0.010 GeneticVariation BEFREE However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk. 24072654

2013

dbSNP: rs2069840
rs2069840
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.010 GeneticVariation BEFREE In conclusion, IL-6 rs2069840 conferred susceptibility to EGFR mutant lung adenocarcinoma in a Hong Kong and Macau never-smoking Chinese population. 29173771

2017

dbSNP: rs2066992
rs2066992
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.010 GeneticVariation BEFREE In the discovery stage, haplotype GGG in three SNPs (rs2069840, rs2069852, rs2066992) of IL-6, synergetic effects of IL-6 rs2069840 and environmental tobacco smoke in the workplace were found to be related to EGFR mutant lung adenocarcinoma. 29173771

2017

dbSNP: rs1800795
rs1800795
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine
0.010 GeneticVariation BEFREE We investigated the inter-relationships of serum levels of the inflammatory proteins CRP and in IL-6, single nucleotide polymorphisms (SNPs) in the CRP (rs1205, rs1130864, rs1800947) and IL6 (rs1800795) genes, and lifestyle factors with colorectal adenoma in a sigmoidoscopy-based case-control study of 271 adenoma cases and 539 age-, sex-, and race/ethnicity-matched controls in Hawaii. 20333461

2010

dbSNP: rs1800795
rs1800795
CUI: C0410702
Disease: Adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis
0.010 GeneticVariation BEFREE This study is to replicate the association between the promoter polymorphisms of matrix metalloproteinase (MMP)-3 (-1171 5A/6A rs3025058) and interleukin (IL)-6 genes (-174G/C rs1800795) and adolescent idiopathic scoliosis (AIS) in a Chinese Han population. 20436380

2010

dbSNP: rs1800797
rs1800797
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer. 29552316

2018

dbSNP: rs1800795
rs1800795
CUI: C1332201
Disease: Adult Diffuse Large B-Cell Lymphoma
Adult Diffuse Large B-Cell Lymphoma
0.010 GeneticVariation BEFREE Given the importance of understanding the genetic variations involved in the pathogenesis of non-Hodgkin's lymphoma (NHL), this pilot study was designed to investigate the impact of CD38 (184C/G; rs6449182) and IL-6 (-174 G/C; rs1800795) gene polymorphism on susceptibility of Egyptians to diffuse large B cell lymphoma (DLBCL); major types of NHL. 25564959

2015

dbSNP: rs1800795
rs1800795
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma
0.020 GeneticVariation BEFREE The IL-6 promoter rs1800795 conferred protection against young adult Hodgkin's disease (ORG 0.68, 95%CI 0.48-0.95). 24059848

2013

dbSNP: rs1800795
rs1800795
CUI: C0220597
Disease: Adult Hodgkin Lymphoma
Adult Hodgkin Lymphoma
0.020 GeneticVariation BEFREE Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma. 29552316

2018

dbSNP: rs1800797
rs1800797
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma
0.010 GeneticVariation BEFREE Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer. 29842912

2018

dbSNP: rs1800795
rs1800795
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma
0.010 GeneticVariation BEFREE Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer. 29842912

2018

dbSNP: rs1800797
rs1800797
CUI: C0741260
Disease: Adult onset asthma
Adult onset asthma
0.010 GeneticVariation BEFREE IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09-1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12-1.90). 26938664

2016

dbSNP: rs1800795
rs1800795
CUI: C0343640
Disease: African Burkitt's lymphoma
African Burkitt's lymphoma
0.010 GeneticVariation BEFREE Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the association between eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes. 25071000

2014

dbSNP: rs1800795
rs1800795
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder)
0.020 GeneticVariation BEFREE We found that two promotor variants in IL-6, especially rs1800795, were predisposing factors for AR with a negative heterosis pattern. 24974143

2014

dbSNP: rs1800795
rs1800795
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder)
0.020 GeneticVariation BEFREE Multivariate logistic regression analyses revealed that individuals with the C allele of IL-6 rs1800795 were susceptible to increased risk of allergic rhinitis, compared to those expressing the G allele (adjusted OR = 1.31; 95%CI = 1.01-1.68). 26909898

2016