|
rs2069845
|
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation.
|
30269203 |
2018 |
|
rs1800795
|
|
Abnormal behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study, we genotyped two interleukin 6 (IL-6) variants (rs2069845 and rs1800795) in 320 suicide attempters, 236 suicide completers, and 341 individuals without any history of psychiatric disorders or suicide ideation.
|
30269203 |
2018 |
|
rs1800796
|
|
Acute appendicitis NOS (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
With this study we investigated the contribution of IL-6 (-572G/C rs1800796) and IL-6R (1:G.154448302 T > C rs7529229) polymorphisms on pathogenesis, and severity of AA in pediatric patients with AA: These results will guide further genetic researches to be performed on the role of IL-6 and IL-6R in AA.
|
26714766 |
2015 |
|
rs1800796
|
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
the results suggest that IL-6 -572 G>C (rs1800796) polymorphism could be involved in the risk of developing ACS in Mexican individuals.
|
20939703 |
2010 |
|
rs1800795
|
|
Acute Chest Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the present study we investigated whether variants at -1082G→A (rs1800896) and -592C→A (rs1800872) of interleukin-10 (IL-10), -1188A→C (rs3212227) of IL-12 p40, -308G→A of tumor necrosis factor-α (TNF-α) (rs1800629), -174G→C of IL-6 (rs1800795) and +874A→T of interferon-γ (IFN-γ) genes (rs2430561) are associated with ACS.
|
22372709 |
2012 |
|
rs1800796
|
|
Acute Coronary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The interleukin 6 -572 G>C (rs1800796) polymorphism is associated with the risk of developing acute coronary syndrome.
|
20939703 |
2010 |
|
rs1800795
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Similar to previous publications, the IL6 donor genotype for rs1800795 was associated with a 20%-50% increased risk for grade IIb-IV aGVHD after unrelated HCT in the allelic (adjusted P = .011) and recessive (adjusted P = .0013) models.
|
22282500 |
2012 |
|
rs1800795
|
|
Acute GVH disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Furthermore, the IL-6R rs4845618 donor genotype showed an association with severe acute graft-versus-host disease (GVHD), whereas the donor genotype of the IL-6 SNP rs1800795 was associated with decreased survival 100 days post-transplant.
|
29513361 |
2018 |
|
rs1800797
|
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.
|
25774595 |
2015 |
|
rs1800796
|
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
|
rs1800795
|
|
Acute pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there were no significant associations between IL-1β (IL-1β +3954 C/T (rs1143634) and IL-1β -511 C/T (rs16944)), IL-6 (IL-6 -174 G/C (rs1800795) and IL-6 -634 C/G (rs1800796)) and IL-10 (IL-10 -1082 A/G (rs1800896), IL-10 -819 C/T (rs1800871) and IL-10 -592 C/A (rs1800872)) gene polymorphisms and AP risk.
|
24072654 |
2013 |
|
rs2069840
|
|
Adenocarcinoma of lung (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, IL-6 rs2069840 conferred susceptibility to EGFR mutant lung adenocarcinoma in a Hong Kong and Macau never-smoking Chinese population.
|
29173771 |
2017 |
|
rs2066992
|
|
Adenocarcinoma of lung (disorder)
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the discovery stage, haplotype GGG in three SNPs (rs2069840, rs2069852, rs2066992) of IL-6, synergetic effects of IL-6 rs2069840 and environmental tobacco smoke in the workplace were found to be related to EGFR mutant lung adenocarcinoma.
|
29173771 |
2017 |
|
rs1800795
|
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the inter-relationships of serum levels of the inflammatory proteins CRP and in IL-6, single nucleotide polymorphisms (SNPs) in the CRP (rs1205, rs1130864, rs1800947) and IL6 (rs1800795) genes, and lifestyle factors with colorectal adenoma in a sigmoidoscopy-based case-control study of 271 adenoma cases and 539 age-, sex-, and race/ethnicity-matched controls in Hawaii.
|
20333461 |
2010 |
|
rs1800795
|
|
Adolescent idiopathic scoliosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study is to replicate the association between the promoter polymorphisms of matrix metalloproteinase (MMP)-3 (-1171 5A/6A rs3025058) and interleukin (IL)-6 genes (-174G/C rs1800795) and adolescent idiopathic scoliosis (AIS) in a Chinese Han population.
|
20436380 |
2010 |
|
rs1800797
|
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, rs1800797 was significantly association with breast cancer, non-Hodgkin's lymphoma, B-cell lymphoma and diffuse large B-cell lymphoma but not gastric cancer.
|
29552316 |
2018 |
|
rs1800795
|
|
Adult Diffuse Large B-Cell Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Given the importance of understanding the genetic variations involved in the pathogenesis of non-Hodgkin's lymphoma (NHL), this pilot study was designed to investigate the impact of CD38 (184C/G; rs6449182) and IL-6 (-174 G/C; rs1800795) gene polymorphism on susceptibility of Egyptians to diffuse large B cell lymphoma (DLBCL); major types of NHL.
|
25564959 |
2015 |
|
rs1800795
|
|
Adult Hodgkin Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Subgroup analysis indicated that rs1800795 was significantly associated with increased risk of cervical cancer, colorectal cancer, breast cancer, prostate cancer, lung cancer, glioma, non-Hodgkin's lymphoma and Hodgkin's lymphoma but not gastric cancer and multiple myeloma.
|
29552316 |
2018 |
|
rs1800795
|
|
Adult Hodgkin Lymphoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The IL-6 promoter rs1800795 conferred protection against young adult Hodgkin's disease (ORG 0.68, 95%CI 0.48-0.95).
|
24059848 |
2013 |
|
rs1800797
|
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800795
|
|
Adult Liver Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800797
|
|
Adult onset asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL6 SNP rs1800797 associated with the risk of adult-onset asthma in a log additive model, with adjusted odds ratio (aOR) 1.31 (95% confidence interval 1.09-1.57), and especially with the risk of atopic adult-onset asthma when compared with non-atopic controls, aOR 1.46 (95% CI 1.12-1.90).
|
26938664 |
2016 |
|
rs1800795
|
|
African Burkitt's lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using case-control samples from western Kenya consisting of 117 eBL cases and 88 ethnically matched healthy controls, we tested for the association between eBL risk and IL-10 (rs1800896, rs1800871, and rs1800872) and IL-6 (rs1800795) promoter single nucleotide polymorphisms (SNPs) as well as IL-10 promoter haplotypes.
|
25071000 |
2014 |
|
rs1800795
|
|
Allergic rhinitis (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
Multivariate logistic regression analyses revealed that individuals with the C allele of IL-6 rs1800795 were susceptible to increased risk of all</span>ergic rhinitis, compared to those expressing the G allele (adjusted OR = 1.31; 95%CI = 1.01-1.68).
|
26909898 |
2016 |
|
rs1800795
|
|
Allergic rhinitis (disorder)
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found that two promotor variants in IL-6, especially rs1800795, were predisposing factors for AR with a negative heterosis pattern.
|
24974143 |
2014 |