Source: ALL

Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13306435
rs13306435
IL6
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study. 21633598

2011

dbSNP: rs13306436
rs13306436
IL6
High density lipoprotein measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs13306436
rs13306436
IL6
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs13306436
rs13306436
IL6
CUI: C1445957
Disease: Serum total cholesterol measurement
Serum total cholesterol measurement
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622

2012

dbSNP: rs1474347
rs1474347
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 GeneticVariation BEFREE We found allele frequencies of rs1800795, rs1800797 and rs1474347 in RA patients differ from control subjects (P = 0.016, 0.024, 0.020, respectively). 25030201

2014

dbSNP: rs1474348
rs1474348
CUI: C0200638
Disease: Eosinophil count procedure
Eosinophil count procedure
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

dbSNP: rs1474348
rs1474348
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017

dbSNP: rs1474348
rs1474348
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017

dbSNP: rs1474348
rs1474348
CUI: C4048328
Disease: cervical cancer
cervical cancer
0.010 GeneticVariation BEFREE Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC. 27722983

2017

dbSNP: rs1524107
rs1524107
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.010 GeneticVariation BEFREE We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ). 30828987

2019

dbSNP: rs1524107
rs1524107
Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes. 27500547

2016

dbSNP: rs1524107
rs1524107
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.010 GeneticVariation BEFREE IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes. 27500547

2016

dbSNP: rs1524107
rs1524107
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.010 GeneticVariation BEFREE In summary, four variations (rs1800796, rs1524107, rs2069840, rs2243250) of the selected candidate SNPs were associated with susceptibility to LDD in our study. 29179499

2017

dbSNP: rs1524107
rs1524107
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma
0.010 GeneticVariation BEFREE We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ). 30828987

2019

dbSNP: rs1524107
rs1524107
CUI: C1857276
Disease: Trichohepatoenteric Syndrome
Trichohepatoenteric Syndrome
0.010 GeneticVariation BEFREE We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome. 20186139

2010

dbSNP: rs1554606
rs1554606
CUI: C0028754
Disease: Obesity
Obesity
0.010 GeneticVariation BEFREE The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population. 24395296

2014

dbSNP: rs1554606
rs1554606
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.010 GeneticVariation BEFREE However, no significant correlations were found when analyzing the association of rs1800795 and rs1554606 with OST risk. 31301734

2019

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation GWASCAT A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. 26545630

2016

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation BEFREE Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold. 22015309

2012

dbSNP: rs1800795
rs1800795
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.720 GeneticVariation BEFREE In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD. 26733302

2016

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. 17003362

2006

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. 18752089

2009

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE This study examined a possible association of the G>C polymorphism at nucleotide -174 in the promoter region of the interleukin-6 (IL-6) gene (rs1800795) with the prevalence of diabetic complications in 235 patients with type 1 and 498 patients with type 2 diabetes. 19140096

2009

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus. 22075267

2012

dbSNP: rs1800795
rs1800795
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes. 25222779

2014