|
rs13306435
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study.
|
21633598 |
2011 |
|
rs13306436
|
|
High density lipoprotein measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs13306436
|
|
Serum HDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs13306436
|
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
rs1474347
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found allele frequencies of rs1800795, rs1800797 and rs1474347 in RA patients differ from control subjects (P = 0.016, 0.024, 0.020, respectively).
|
25030201 |
2014 |
|
rs1474348
|
|
Eosinophil count procedure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs1474348
|
|
Cervix carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1474348
|
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1474348
|
|
cervical cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haploview analysis demonstrated high linkage disequilibrium (LD) between rs2069845, rs2069840, rs1474348 and rs1800795, and 6-locus haplotype analysis identified GACCCA haplotype to be positively associated with increased CC, while GAGGGG haplotype was negatively associated with CC, thus suggesting a protective role for this haplotype in CC.
|
27722983 |
2017 |
|
rs1524107
|
|
Trichohepatoenteric Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
We examined the role of the IL-6 (rs1524107-C/T) and IL-6 receptor (IL-6R, rs8192284-A/C, Asp358Ala) SNPs in modulating IL-6 levels and the syndrome.
|
20186139 |
2010 |
|
rs1524107
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes.
|
27500547 |
2016 |
|
rs1524107
|
|
Lumbar disc disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, four variations (rs1800796, rs1524107, rs2069840, rs2243250) of the selected candidate SNPs were associated with susceptibility to LDD in our study.
|
29179499 |
2017 |
|
rs1524107
|
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1524107
|
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed a significant increase in risk of endometrial cancer of rs1524107 (IL6) (T/C, OR = 1.61, 95% CI = 1.09-2.37, p = 1.55 × 10<sup>-2</sup> ), rs2066992 (IL 6) (OR = 3.09, 95% CI = 2.11-4.53, p = 3.13 × 10<sup>-9</sup> ).
|
30828987 |
2019 |
|
rs1524107
|
|
Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
IL-6 gene polymorphisms rs1800796 and rs1524107 may serve as predictors of progression of nephropathy in Chinese patients with type 2 diabetes.
|
27500547 |
2016 |
|
rs1554606
|
|
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population.
|
24395296 |
2014 |
|
rs1554606
|
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant correlations were found when analyzing the association of rs1800795 and rs1554606 with OST risk.
|
31301734 |
2019 |
|
rs1800795
|
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
|
rs1800795
|
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin.
|
26545630 |
2016 |
|
rs1800795
|
|
Alzheimer's Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold.
|
22015309 |
2012 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
|
19267250 |
2009 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
|
rs1800795
|
|
Prostate carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)].
|
24446297 |
2014 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001).
|
30854108 |
2019 |
|
rs1800795
|
|
Malignant neoplasm of prostate
|
|
0.070 |
GeneticVariation
|
BEFREE |
The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)).
|
30345492 |
2019 |