Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4 		0.520 Biomarker disease CTD_human Serotonin transporter linked promoter (polymorphism) in the serotonin transporter gene may be associated with antidepressant-induced mania in bipolar disorder. 16395126 2006
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4 		0.520 Biomarker disease BEFREE The serotonin transporter (5-HTT) is the selective site of action of most proserotonergic compounds used to treat bipolar depression. 11386982 2001
Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4 		0.520 Biomarker disease CTD_human Catechol o-methyltransferase, serotonin transporter, and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. 11772685 2002
Entrez Id: 6526
Gene Symbol: SLC5A3
SLC5A3 		0.300 Biomarker disease CTD_human Sodium-myo-inositol co-transporter (SMIT-1) mRNA is increased in neutrophils of patients with bipolar 1 disorder and down-regulated under treatment with mood stabilizers. 16420717 2007
Entrez Id: 27036
Gene Symbol: SIGLEC7
SIGLEC7 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 22941
Gene Symbol: SHANK2
SHANK2 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 5265
Gene Symbol: SERPINA1
SERPINA1 		0.300 Biomarker disease CTD_human Art, alpha-1-antitrypsin polymorphisms and intense creative energy: blessing or curse? 17659342 2007
Entrez Id: 6326
Gene Symbol: SCN2A
SCN2A 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
Entrez Id: 6285
Gene Symbol: S100B
S100B 		0.500 Biomarker disease CTD_human Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. 15581912 2004
Entrez Id: 6285
Gene Symbol: S100B
S100B 		0.500 Biomarker disease RGD Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain. 15581912 2004
Entrez Id: 6285
Gene Symbol: S100B
S100B 		0.500 Biomarker disease CTD_human Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia. 16476148 2006
Entrez Id: 6196
Gene Symbol: RPS6KA2
RPS6KA2 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
Entrez Id: 22999
Gene Symbol: RIMS1
RIMS1 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.300 Biomarker disease CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2004
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.300 Biomarker disease CTD_human Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. 11126396 2000
Entrez Id: 5649
Gene Symbol: RELN
RELN 		0.300 Biomarker disease CTD_human GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in cerebellum. 15560956 2005
Entrez Id: 5816
Gene Symbol: PVALB
PVALB 		0.300 Biomarker disease CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.020 Biomarker disease BEFREE A search strategy was developed using the terms: "Bipolar disorder" or "Bipolar mania" or "Bipolar depression" or "Bipolar mixed" or "Bipolar euthymic" and "Celecoxib" or "Cyclooxygenase-2 inhibitors" or "Cox-2 inhibitors" as text words and Medical Subject Headings (i.e., MeSH and EMTREE) and searched. 30398124 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2 		0.020 Biomarker disease BEFREE Modulation of the inflammatory response through targeted inhibition of the enzyme COX-2 by means of CBX reduces TRBDD and augments and accelerates treatment response in an efficacious and safe manner. 31630035 2020
Entrez Id: 5715
Gene Symbol: PSMD9
PSMD9 		0.010 GeneticVariation disease BEFREE PSMD9 is located in the chromosome 12q24 locus, which per se is in linkage with depression, bipolar disorder and anxiety. 24648162 2014
Entrez Id: 11168
Gene Symbol: PSIP1
PSIP1 		0.010 Biomarker disease BEFREE Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. 28761093 2017
Entrez Id: 5463
Gene Symbol: POU6F1
POU6F1 		0.010 Biomarker disease BEFREE Brain 5-HT1A binding potential (BP(F) = B(max)/K(D), where B(max) = total available receptors, and 1/K(D) = ligand affinity) was measured in 32 currently depressed, medication-free BD subjects and 47 controls. 19278673 2009
Entrez Id: 5454
Gene Symbol: POU3F2
POU3F2 		0.300 Biomarker disease CTD_human Genome-wide association study identifies 30 loci associated with bipolar disorder. 31043756 2019
Entrez Id: 5444
Gene Symbol: PON1
PON1 		0.010 AlteredExpression disease BEFREE The studies support decreased PON1 activity as determined using phenylacetate (i.e., arylesterase or AREase) as a substrate, in depression, bipolar disorder, generalized anxiety disorder (GAD) and schizophrenia, especially in antipsychotic-free patients. 30592255 2019