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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls.
|
15612980 |
2005 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease.
|
12417280 |
2002 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism.
|
12049191 |
2002 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C677T mutation of the methylenetetrahydrofolate reductase gene is not associated with the risk of coronary artery disease or venous thrombosis among Chinese in Taiwan.
|
11096270 |
2001 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common mutation (nucleotide 677 C-->T) has been described recently in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which results in a valine for alanine substitution, a thermolabile enzyme, and a tendency to elevate plasma homocysteine levels and which has been proposed to contribute importantly to coronary artery disease.
|
8994411 |
1997 |
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rs1217691063
|
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0.100 |
GeneticVariation |
BEFREE |
The effect of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, traditionally associated with ischaemic heart disease (IHD), was assessed in a Spanish population.
|
12220440 |
2002 |
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rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Sex-specific effect of the thermolabile C677T mutation in the methylenetetrahydrofolate reductase gene on angiographically assessed coronary artery disease in Brazilians.
|
18075008 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
|
18403793 |
2008 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have shown that a common mutation (nucleotide 677 C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene may contribute to mild hyperhomocysteinemia and, therefore, to the incidence of coronary artery disease.
|
11319193 |
2001 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The homozygous C677T genotype has previously been associated with coronary heart disease in Ireland.
|
9974399 |
1999 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The C677T polymorphism of 5,10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20637366 |
2010 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis.
|
12387655 |
2002 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The objective of our study is to evaluate the single locus and combined effects of three different genetic polymorphisms (methylenetetrahydrofolate reductase C677T polymorphism, plasminogen activator inhibitor 4G/5G polymorphism, and endothelial nitric oxide synthase 3-27 base pairs repeat polymorphism) on the presence and extent of coronary artery disease in patients with early-onset coronary artery disease.
|
16845248 |
2006 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
MTHFR 677 C-->T mutation: a predictor of early-onset coronary artery disease risk.
|
11562338 |
2001 |
|
rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Mutation C677T of methylenetetrahydrofolate reductase gene is not associated with coronary artery disease, but possibly with albuminuria, in type 2 diabetic patients.
|
9806473 |
1998 |
|
rs1799983
|
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|
0.100 |
GeneticVariation |
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
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rs1799983
|
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0.100 |
GeneticVariation |
BEFREE |
In conclusion, the protective HO1 promoter polymorphism correlates with a lower coronary artery plaque burden, whereas the protective ENOS 894 G/T polymorphism seems to favourably influence changes of coronary artery plaque composition during statin therapy, but has no significant correlation to the magnitude of coronary atherosclerosis.
|
22123460 |
2011 |
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rs1799983
|
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0.100 |
GeneticVariation |
BEFREE |
G894T polymorphism of eNOS gene was not associated with foot ulcer and diabetic complications, except in the presence of atherosclerotic heart disease.
|
20642368 |
2010 |
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rs1799983
|
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|
0.100 |
GeneticVariation |
BEFREE |
This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population.
|
20470943 |
2010 |
|
rs1799983
|
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|
0.100 |
GeneticVariation |
BEFREE |
Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran.
|
21602253 |
2012 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease.
|
15595935 |
2005 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07).
|
17108813 |
2006 |
|
rs1799983
|
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|
0.100 |
GeneticVariation |
BEFREE |
However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease.
|
17018701 |
2006 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common variant of the endothelial nitric oxide synthase (Glu298-->Asp) is a major risk factor for coronary artery disease in the UK.
|
10510054 |
1999 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population.
|
15483745 |
2004 |