Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease. 17018701

2006

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls. 16616056

2006

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Paraoxonase-1 (PON1) activity, but not PON1(Q192R) phenotype, is a predictor of coronary artery disease in a middle-aged Serbian population. 17032132

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE No strong evidence exists to support an association of the MTHFR 677 C-->T polymorphism and coronary heart disease in Europe, North America, or Australia. 16216822

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy, nephropathy, atherosclerosis and coronary heart disease. 16274479

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We studied several single nucleotide polymorphisms (SNP) in Hcy-regulating genes [methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C; methionine synthase (MS) A2756G; methionine synthase reductase (MTRR) A66G] in relation to total plasma Hcy levels, transplant coronary artery disease and thromboembolic episodes in 84 heart transplant patients, and we compared the incidence of these polymorphisms with those in a healthy adult controls. 15612980

2005

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase (eNOS), which produces NO, plays an important role in the endothelial function under a wide range of physiological conditions. eNOS exon 7 polymorphism (Glu298Asp, G894T) has been considered to influence the risk of coronary artery disease. 15595935

2005

dbSNP: rs699
rs699
AGT
0.100 GeneticVariation BEFREE The angiotensinogen M235T variant was analyzed in 871 consecutive patients with clinically suspected coronary artery disease submitted to coronary angiography study. 16045904

2005

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease. 15353918

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The 5,10-methylenetetrahydrofolate reductase gene (MTHFR) 677C-->T polymorphism modifies the risk of coronary artery disease and colon cancer and is related to plasma concentrations of total homocysteine (tHcy). 15447919

2004

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population. 15483745

2004

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. 15214960

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Prevalence and role of methylenetetrahydrofolate reductase 677 C-->T and 1298 A-->C polymorphisms in coronary artery disease in Arabs. 14521457

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We investigated the influence of elevated homocysteine plasma levels and 2 polymorphisms, 677C/T and 1298A/C, of the methylenetetrahydrofolate reductase (MTHFR) gene on the risk of restenosis after stenting in patients with symptomatic coronary artery disease. 14604831

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease. 12522558

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. 12801615

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The C677T mutation in methylenetetrahydrofolate reductase gene, plasma homocysteine concentration and the risk of coronary artery disease. 14560345

2003

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations. 12641536

2003

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE Interactive effects of the ACE DD polymorphism with the NOS III homozygous G849T (Glu298-->Asp) variant in determining endothelial function in coronary artery disease. 14989558

2003

dbSNP: rs662
rs662
0.100 GeneticVariation BEFREE Different pattern of association of paraoxonase Gln192-->Arg polymorphism with sporadic late-onset Alzheimer's disease and coronary artery disease. 12618290

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease. 12417280

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism. 12049191

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The effect of the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, traditionally associated with ischaemic heart disease (IHD), was assessed in a Spanish population. 12220440

2002

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis. 12387655

2002

dbSNP: rs1799983
rs1799983
0.100 GeneticVariation BEFREE An endothelial nitric oxide synthase gene (NOS3) polymorphism in exon 7 (G894T), resulting in Glu298Asp substitution at protein level, has been associated with myocardial infarction, hypertension and coronary atherosclerosis in some populations. 12113283

2002