|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Homozygosity for the IL7R exon 6 rs6897932 C allele is associated with a higher risk for MS in our Dutch population.
|
21543551 |
2011 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
For MS, one of the first discoveries to emerge in this new era was the association with rs6897932[T244I] in the interleukin-7 receptor alpha chain (IL7RA) gene (Gregory et al. in Nat Genet 39(9):1083-1091, 2007; International Multiple Sclerosis Genetics Consortium in N Engl J Med 357(9):851-862, 2007; Lundmark in Nat Genet 39(9):1108-1113, 2007), a discovery that was accompanied by functional data that suggest this variant is likely to be causative rather than a surrogate proxy (Gregory et al. in Nat Genet 39(9):1083-1091, 2007).
|
20112030 |
2010 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans.
|
20194581 |
2010 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Here, we show that the IL2RA genotypes differentially affects soluble IL-2RA (sIL-2RA) levels in MS cases vs healthy controls; the two variants associated with MS (rs12722489 and rs2104286) account for 15 and 18% of the total variance in log(10)-transformed sIL-2RA concentration in control subjects but less so in subjects with MS (2 and 5%), suggesting that perturbations associated with disease or treatment may influence sIL-2RA levels in subjects with MS.
|
19155502 |
2009 |
|
rs2104286
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs2104286
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association of only one (rs2104286) of the two IL2RA SNPs identified in the recently performed genome-wide association study of MS.
|
19125193 |
2009 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We replicated the association of exon 6 variation (rs6897932) in IL7RA with MS.
|
19231135 |
2009 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The C allele of a single nucleotide polymorphism (SNP), rs6897932, located in the interleukin-7 receptor alpha chain (IL7RA) was recently found to be associated with multiple sclerosis and Type I diabetes.
|
19744146 |
2009 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings in our sample support previous reported association studies between IL7RA rs6897932 and MS.
|
18721276 |
2008 |
|
rs6897932
|
|
|
0.900 |
GeneticVariation |
BEFREE |
It is estimated that the C allele of a single nucleotide polymorphism, rs6897932, within the alternative spliced exon 6 of IL7RA is involved in about 30% of MS cases.
|
18461312 |
2008 |
|
rs2104286
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs6897932
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Risk alleles for multiple sclerosis identified by a genomewide study.
|
17660530 |
2007 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
DNA was extracted from blood in order to analyse EBV and HHV-6 viral load by quantitative real-time polymerase chain reaction and to genotype MS-related single nucleotide polymorphisms (rs3135388, rs2248359 and rs12368653) when possible.
|
29996002 |
2018 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Presence of the rs3135388 polymorphism tagging the major MS risk allele HLA-DRB1*15:01 allele was determined as well.
|
28130760 |
2017 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We genotyped a cohort of 1033 MS patients and 644 healthy controls with a consistent genetic background for the 57 non-MHC variants reported to be associated with MS by the first large GWAS as well as the HLA DRB1*1501 tagging SNP rs3135388.
|
26011527 |
2015 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our findings show for the first time that the rs3135388</span> polymorphism is a strong risk factor for MS in the Slovak population.
|
25958306 |
2015 |
|
rs3135388
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Genetic variants are major determinants of CSF antibody levels in multiple sclerosis.
|
25616667 |
2015 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.
|
23186557 |
2013 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We analyzed the allelic and genotype frequency of VDR rs2228570, rs731236, and HLADRB1*1501 (rs3135388) in 303 patients with MS and 310 healthy controls, using TaqMan Assays.
|
23840333 |
2013 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We observed a trend for association of rs3135388 (HLA-DRB1*1501, p < 0.01), rs7090530 (IL2RA, p < 0.026) and rs1841770 (ZIC1, p < 0.017) with a younger age at MS onset and of rs12044852 (CD58, p < 0.035) with shorter time to reach EDSS6.
|
22411505 |
2012 |
|
rs3135388
|
|
|
0.890 |
GeneticVariation |
BEFREE |
In quantitative terms, the MS-risk AA genotype carriers of rs3135388 were associated with 15.7-, 5.2- and 8.3-fold higher expression of DQB1, DRB5 and DRB1, respectively, than the non-risk GG carriers.
|
22253788 |
2012 |
|
rs3135388
|
|
A |
0.890 |
GeneticVariation |
GWASDB |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |
|
rs3135388
|
|
A |
0.890 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
|
19525953 |
2009 |