|
rs17122021
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs17122021
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs2562456
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs2562456
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study of acute post-surgical pain in humans.
|
19207018 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The most pronounced N40D effects were found in brain regions involved in the sensory processing of pain intensity.
|
19116204 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Regarding the A118G SNP in exon 1, in a cold pressor-induced pain test before surgery, less analgesic effects of fentanyl were shown in subjects carrying the minor G allele of the A118G SNP (median of difference between pain perception latencies before and after fentanyl injection [PPLpost-PPLpre]: 12s) compared with subjects not carrying this allele (PPLpost-PPLpre: 15s, p=0.046).
|
19783098 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This discourages basing personalized therapeutic concepts of pain therapy on OPRM1 118A>G genotyping at the present state of evidence.
|
19683391 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, dACC activity mediated the relationship between the A118G polymorphism and dispositional sensitivity to rejection, suggesting that this is a critical site for mu-opioid-related influence on social pain.
|
19706472 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that ethnicity and OPRM 118A>G genotype are independent and significant contributors to variation in pain perception and postoperative morphine use in patients undergoing cesarean delivery.
|
19545447 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was a tendency towards increased pain in a gene dose-dependent manner with the mu-opioid receptor variant OPRM1 118A>G.
|
19514130 |
2009 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) in the human mu-opioid receptor gene (OPRM1 A118G) has been widely studied for its association in a variety of drug addiction and pain sensitivity phenotypes; however, the extent of these adaptations and the mechanisms underlying these associations remain elusive.
|
19528658 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val158Met and thermal pain measures were not related.
|
19464960 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetics-based personalized approaches to pain management have received a setback because of the nonreproducibility of functional genetic associations such as the pain-modulatory effect of the catechol-O-methyl transferase (COMT) gene 472G>A single-nucleotide polymorphism.
|
18548001 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism.
|
19547755 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (val(158)met) position, designated as low (LPS), average (APS), and high pain sensitive (HPS), are associated with experimental pain sensitivity and risk of developing chronic musculoskeletal pain conditions.
|
19365560 |
2009 |
|
rs373611092
|
|
|
0.050 |
GeneticVariation |
BEFREE |
There was a tendency towards increased pain in a gene dose-dependent manner with the mu-opioid receptor variant OPRM1 118A>G.
|
19514130 |
2009 |
|
rs11466112
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF.
|
19038341 |
2009 |
|
rs5275
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Controlling for these nongenetic covariates, we found that patients with CC genotypes for PTGS2 exon10+837T>C (rs5275) were at lower risk for severe pain (OR, 0.33; 95% CI, 0.11-0.97) and an additive model for TNFalpha -308GA (rs1800629; OR, 1.67; 95% CI, 1.08-2.58) and NFKBIA Ex6+50C>T (rs8904) was predictive of severe pain (OR, 0.64; 95% CI, 0.43-0.93).
|
19773451 |
2009 |
|
rs563649
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Examination of polymorphisms within the human OPRM1 gene locus identified strong association between single nucleotide polymorphism (SNP) rs563649 and individual variations in pain perception.
|
19103668 |
2009 |
|
rs6280
|
|
|
0.020 |
GeneticVariation |
BEFREE |
DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls.
|
19464960 |
2009 |
|
rs10483639
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of the "pain-protective" (CAT - C allele of rs10483639, A allele of rs3783641 and T allele of rs8007267) haplotype was compared to the frequency of the other haplotypes between cases and controls using the chi2 test.
|
19775452 |
2009 |
|
rs1288779666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a tendency towards increased pain in a gene dose-dependent manner with the mu-opioid receptor variant OPRM1 118A>G.
|
19514130 |
2009 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Controlling for these nongenetic covariates, we found that patients with CC genotypes for PTGS2 exon10+837T>C (rs5275) were at lower risk for severe pain (OR, 0.33; 95% CI, 0.11-0.97) and an additive model for TNFalpha -308GA (rs1800629; OR, 1.67; 95% CI, 1.08-2.58) and NFKBIA Ex6+50C>T (rs8904) was predictive of severe pain (OR, 0.64; 95% CI, 0.43-0.93).
|
19773451 |
2009 |
|
rs76060075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a tendency towards increased pain in a gene dose-dependent manner with the mu-opioid receptor variant OPRM1 118A>G.
|
19514130 |
2009 |
|
rs8904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Controlling for these nongenetic covariates, we found that patients with CC genotypes for PTGS2 exon10+837T>C (rs5275) were at lower risk for severe pain (OR, 0.33; 95% CI, 0.11-0.97) and an additive model for TNFalpha -308GA (rs1800629; OR, 1.67; 95% CI, 1.08-2.58) and NFKBIA Ex6+50C>T (rs8904) was predictive of severe pain (OR, 0.64; 95% CI, 0.43-0.93).
|
19773451 |
2009 |