|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The A118G polymorphism of mu-opioid receptor may be closely associated with DFU pain in 34 out of 50 patients in the painless group and in 5 out of 15 patients in the painful group.
|
19303332 |
2010 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common single nucleotide polymorphism (SNP), A118G, in the mu-opioid receptor gene can affect opioid function and, consequently, has been suggested to contribute to individual variability in pain management and drug addiction.
|
20074870 |
2010 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A118G: We found that the variant G allele was associated with reduced antinociceptive effect as measured by pain tolerance thresholds to single electrical nerve stimulation (8% increase vs. 25% for the wild-type carriers, P = 0.007).
|
19845769 |
2010 |
|
rs1799971
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The A118G polymorphism had a gene-dose-dependent effect on electrical pain tolerance threshold.
|
20003118 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.
|
21049025 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
More generally, apart from one report that focused on pain-induced opioid release, this is the first functional neuroimaging study showing an effect of the COMT val158met polymorphism on cerebral pain processing.
|
20509977 |
2010 |
|
rs6265
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.
|
21049025 |
2010 |
|
rs759834365
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.
|
21049025 |
2010 |
|
rs6746030
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The A allele of rs6746030 was associated with an altered pain threshold and the effect mediated through C-fiber activation.
|
20212137 |
2010 |
|
rs11466112
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V).
|
19945432 |
2010 |
|
rs165599
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The rs165599 SNP, which has previously been associated with response of depressive symptoms to treatment in patients with MDD, did not impact baseline pain in either gender.
|
20627703 |
2010 |
|
rs2032582
|
|
|
0.020 |
GeneticVariation |
BEFREE |
G2677T/A: The carriers of the variant T allele had a better antinociceptive effect of oxycodone than the carriers of the wild-type genotype in the cold pressor test (25% reduction vs. 15%, P = 0.015 in the discomfort rating and 25% reduction vs. 12%, P = 0.007 in the pain time AUC) and less adverse drug reactions.
|
19845769 |
2010 |
|
rs748653984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V).
|
19945432 |
2010 |
|
rs778056858
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V).
|
19945432 |
2010 |
|
rs1042713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADRB2 SNPs rs12654778 and rs1042713 were associated either with CWP alone (p=0.02 for both) or with position along pain spectrum (pain status; p=0.04).
|
20167428 |
2010 |
|
rs12654778
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADRB2 SNPs rs12654778 and rs1042713 were associated either with CWP alone (p=0.02 for both) or with position along pain spectrum (pain status; p=0.04).
|
20167428 |
2010 |
|
rs1378978590
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V).
|
19945432 |
2010 |
|
rs200207721
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.
|
21049025 |
2010 |
|
rs28935468
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Families of ARSD and InterRett subjects with a C-terminal (OR 2.6; 95% CI 0.8-8.0), p.R168X (OR 2.1; 95% CI 0.7-6.1), or p.R306C (OR 2.7; 95% CI 0.8-9.6) mutation were more likely to report decreased sensitivity to pain.
|
20425824 |
2010 |
|
rs3813034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between personality, pain threshold and a single nucleotide polymorphism (rs3813034) in the 3'-untranslated region of the serotonin transporter gene (SLC6A4).
|
20303273 |
2010 |
|
rs4778889
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the rs4778889 T/C polymorphism of the IL-16 gene may be associated with risk of endometriosis in the Chinese population, especially in patients with pain phenotype.
|
20662556 |
2010 |
|
rs61748421
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Families of ARSD and InterRett subjects with a C-terminal (OR 2.6; 95% CI 0.8-8.0), p.R168X (OR 2.1; 95% CI 0.7-6.1), or p.R306C (OR 2.7; 95% CI 0.8-9.6) mutation were more likely to report decreased sensitivity to pain.
|
20425824 |
2010 |
|
rs61751364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Families of ARSD and InterRett subjects with a C-terminal (OR 2.6; 95% CI 0.8-8.0), p.R168X (OR 2.1; 95% CI 0.7-6.1), or p.R306C (OR 2.7; 95% CI 0.8-9.6) mutation were more likely to report decreased sensitivity to pain.
|
20425824 |
2010 |
|
rs769540300
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, genetic effects (COMT Val(158)Met and BDNF Val(66)Met) on experimental pain were moderated by the presence of chronic pain.
|
21049025 |
2010 |
|
rs769854785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, a missense point mutation was found in the NGFB gene (C661T, leading to the aminoacid substitution R100W) of individuals affected by a form of hereditary loss of pain perception (hereditary sensory and autonomic neuropathy type V, HSAN V).
|
19945432 |
2010 |