|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this context, a genetic association study was carried out between two eNOS polymorphisms (the ecNOS4a/b VNTR and the G894T substitution) in a sample of 101 nuclear families having one affected offspring of ischemic heart disease (IHD).
|
12503100 |
2003 |
|
rs11053646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein.
|
12646194 |
2003 |
|
rs544456198
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein.
|
12646194 |
2003 |
|
rs752596535
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the OLR1 gene and found a single nucleotide polymorphism (SNP), G501C, in patients with ischemic heart disease from a single family, which resulted in the missense mutation of K167N in LOX-1 protein.
|
12646194 |
2003 |
|
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group.
|
12805070 |
2003 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aims to determine whether the two major mutations of the haemochromatosis (HFE) gene (C282Y and H63D) are associated with ischaemic heart disease (IHD) or myocardial infarction (MI).
|
12923017 |
2003 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aims to determine whether the two major mutations of the haemochromatosis (HFE) gene (C282Y and H63D) are associated with ischaemic heart disease (IHD) or myocardial infarction (MI).
|
12923017 |
2003 |
|
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Possession of the C34T (Glu12Stop) nonsense mutation in the AMP-deaminase 1 (AMPD1) gene has been shown to be associated with improved prognosis in heart failure and ischemic heart disease.
|
14499869 |
2003 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using self-reported data on ischemic heart disease to evaluate the impact of the PON 192Q/R polymorphism on susceptibility to CHD, we found only a nonsignificant trend of 192RR homozygosity in women being a risk factor.
|
15241482 |
2004 |
|
rs5498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the combined transmission disequilibrium test (TDT)/sib-TDT and the pedigree disequilibrium test (PDT), no association between the ICAM-1 K469E polymorphism and IHD was found.
|
15379751 |
2004 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Using robust family-based association tests specifically designed for the study of complex diseases, we found no evidence that the G894T polymorphism of the eNOS gene has a significant role in the development of IHD in our population.
|
15523316 |
2004 |
|
rs1042579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several published studies have shown that the Ala455Val thrombomodulin polymorphism is associated with ischemic heart disease, but none has examined the association with stroke.
|
15574195 |
2004 |
|
rs147377392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several published studies have shown that the Ala455Val thrombomodulin polymorphism is associated with ischemic heart disease, but none has examined the association with stroke.
|
15574195 |
2004 |
|
rs28357984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mitochondrial DNA 5178 C/A (mt5178 C/A), namely NADH dehydrogenase subunit 2 237 Leu/Met, polymorphism is as reported in literature associated with longevity and susceptibility to ischemic heart disease or cerebrovascular disorders in the Japanese population.
|
15680495 |
2005 |
|
rs281860391
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The emerging data are quite conflicting and do not provide definitive evidence for a role of these gene variants in the pathogenesis of IHD; a possible exception is the G252A and polymorphism in the TNF-beta gene (also known as lymphotoxin-alpha) which, in a comprehensive genome-scan linkage analysis of unrelated Japanese, but not in a smaller German population, was linked to myocardial infarction.
|
15760675 |
2005 |
|
rs745738344
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The emerging data are quite conflicting and do not provide definitive evidence for a role of these gene variants in the pathogenesis of IHD; a possible exception is the G252A and polymorphism in the TNF-beta gene (also known as lymphotoxin-alpha) which, in a comprehensive genome-scan linkage analysis of unrelated Japanese, but not in a smaller German population, was linked to myocardial infarction.
|
15760675 |
2005 |
|
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease.
|
16021915 |
2005 |
|
rs2295490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 100 additional type 2 diabetic patients who suffered from myocardial ischemia, age at myocardial ischemia was progressively and significantly (P = 0.03) reduced from Q84Q to Q84R to R84R individuals.
|
16123373 |
2005 |
|
rs138880920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for an ABCA1 mutation (K776N) conferred two- to three-fold risk of IHD in 37 participants in the Copenhagen City Heart study.
|
16226177 |
2005 |
|
rs1144507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD).
|
16289551 |
2006 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, a multivariate logistic regression analysis in which age, gender, body mass index (BMI), and ischemic heart disease were included as independent variables indicated that Ser326Cys could be an independent factor affecting tooth loss (OR, 3.191; 95%CI, 1.174-8.672).
|
16538639 |
2006 |
|
rs268
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Pairwise combinations of D9N with -219G > T in APOE and N291S and S447X in LPL significantly improved the prediction of IHD (P = 0.05 in women, P = 0.04 in men, P = 0.03 in men, respectively) beyond smoking, diabetes and hypertension, and identified subgroups of individuals (n = 6-94) with highly significant HRs of 1.92-4.35.
|
17006673 |
2007 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.
|
17264883 |
2007 |
|
rs2066714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs.
|
17951323 |
2008 |
|
rs2066718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs.
|
17951323 |
2008 |