|
rs4359426
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of the GG genotype at SNP rs4508917 in CXCL10 gene was higher, whereas the frequency of the AA genotype at SNP rs4359426 in CCL22 gene was lower in total patients with IHD as compared with healthy subjects (P<0.04 and P<0.002, respectively).
|
27152707 |
2016 |
|
rs6749704
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the CXCL10, CCL20 and CCL22 levels and the single nucleotide polymorphisms (SNPs) rs4508917, rs6749704 and rs4359426 in chemokine genes in patients with IHD to clarify any association.
|
27152707 |
2016 |
|
rs884164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Importantly, analysis of a human cohort with suspected coronary artery disease showed that a common noncoding polymorphism, rs884164, decreases the cardiac expression of PLIN5 and is associated with reduced heart function following myocardial ischemia, indicating a role for Plin5 in cardiac dysfunction.
|
27376234 |
2016 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities.
|
25413568 |
2015 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
rs11234027
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
rs12794714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
rs33972313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SLC23A1 rs33972313 G allele was associated with 11% higher plasma vitamin C. The multivariable adjusted HRs for highest compared with lowest fruit and vegetable intakes were 0.87 (95% CI: 0.78, 0.97; P = 0.01) for ischemic heart disease and 0.80 (95% CI: 0.73, 0.88; P < 0.001) for all-cause mortality.
|
25948669 |
2015 |
|
rs7944926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
|
rs1239681664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
|
rs12817819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ATP2B1 rs12817819 A allele is associated with increased risk for RHTN in hypertensive participants with documented CAD or suspected ischemic heart disease.
|
25385345 |
2014 |
|
rs567798234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease.
|
24431031 |
2014 |
|
rs6742078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
UGT1A1 rs6742078 TT versus GG genotype was associated with 95% increased bilirubin levels (P < 0.001); TT versus GG genotype was associated with odds ratios (ORs) of 1.03 (95% CI, 0.96-1.11; P = 0.73) for IHD and 1.01 (95% CI, 0.92-1.12; P = 0.68) for MI.
|
22805420 |
2013 |
|
rs77375493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
JAK2 V617F somatic mutation positives versus negatives had higher erythrocyte (P = 2 × 10(-5) ), thrombocyte (P = 2 × 10(-16) ), and leucocyte (P = 4 × 10(-9) ) counts, and had 2·7-/2·5-fold risk of cancer (prevalent/incident), 44-/28-fold risk of haematological cancer, 221-/97-fold risk of myeloproliferative cancer, 2·2-/1·2-fold risk of ischaemic heart disease, and 3·1-/1·0-fold risk of venous thromboembolism.
|
23116358 |
2013 |
|
rs10903323
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MSRA rs10903323 gene polymorphism may be implicated in the increased risk to develop CV events, in particular ischaemic heart disease, observed in RA patients.
|
22657383 |
2012 |
|
rs1800888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population.
|
21883537 |
2012 |
|
rs3751143
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The common loss-of-function variant rs3751143 was significantly associated with a decreased risk of IHD in smokers (P = 0.03) as well as decreased risk of IS (OR 0.89; 95% CI = 0.81-0.97; P = 0.012).
|
22662160 |
2012 |
|
rs750249283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next, we genotyped 10 237 individuals from the Copenhagen City Heart Study for the identified variants and determined the effect on lipid and lipoprotein levels and on risk of myocardial infarction (MI) and ischemic heart disease (IHD). g.-376C>T, g.-311T>A, and Ser630Leu predicted risk of MI in the Copenhagen City Heart Study, with hazard ratios of 2.2 (95% confidence interval: 1.2-4.3), 1.7 (1.0-2.9), and 7.5 (1.9-30), respectively.
|
22155456 |
2012 |
|
rs872129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
High YKL-40 levels (>85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD.
|
22937056 |
2012 |
|
rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings indicate not any significant association between collateral formation and polymorphic variants of HIF-1A and P582S substitution does not appear to influence the collateral formation in patients with myocardial ischemia.
|
21945026 |
2011 |
|
rs1260326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI.
|
21071687 |
2011 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous.
|
21536090 |
2011 |
|
rs1800796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between single-nucleotide polymorphisms -174G/C (rs1800795) and -572G/C (rs1800796) in the interleukin-6 (IL-6) gene promoter region and ischemic heart disease (IHD)/ischemic stroke (IS) remains controversial and ambiguous.
|
21536090 |
2011 |
|
rs2954029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI.
|
21071687 |
2011 |