|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease.
|
12417280 |
2002 |
|
rs1239681664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
|
rs1260326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI.
|
21071687 |
2011 |
|
rs12713559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterzygous carriers of the Arg3531Cys mutation in the general population did not have higher-than-normal plasma cholesterol levels or an increased risk of ischemic heart disease (odds ratio; 1.4; 95 percent confidence interval, 0.2 to 11; P=0.54).
|
9603795 |
1998 |
|
rs12794714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two 25(OH)D reducing genetic variants in the DCHR7 gene (rs7944926 and rs11234027) and two in the CYP2R1 gene (rs10741657 and rs12794714) were genotyped in 92 416 participants of Danish descent, of whom 14 455 developed ischaemic heart disease (ICD-8:410-414; ICD-10:I20-I25) and 7061 myocardial infarction (ICD-8:410: ICD-10:I21-I22) from 1977 through 2011.
|
25981321 |
2015 |
|
rs12817819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ATP2B1 rs12817819 A allele is associated with increased risk for RHTN in hypertensive participants with documented CAD or suspected ischemic heart disease.
|
25385345 |
2014 |
|
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease.
|
24431031 |
2014 |
|
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Possession of the C34T mutation in AMP deaminase (AMPD1) gene has been shown to be associated with attenuation of the progression of heart failure and improved survival in ischemic heart disease.
|
16021915 |
2005 |
|
rs1320702652
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Possession of the C34T (Glu12Stop) nonsense mutation in the AMP-deaminase 1 (AMPD1) gene has been shown to be associated with improved prognosis in heart failure and ischemic heart disease.
|
14499869 |
2003 |
|
rs138880920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for an ABCA1 mutation (K776N) conferred two- to three-fold risk of IHD in 37 participants in the Copenhagen City Heart study.
|
16226177 |
2005 |
|
rs147377392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several published studies have shown that the Ala455Val thrombomodulin polymorphism is associated with ischemic heart disease, but none has examined the association with stroke.
|
15574195 |
2004 |
|
rs17057255
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped participants from the Copenhagen City Heart Study (n=10 352), the Copenhagen General Population Study (n=26 042), the Copenhagen Carotid Stroke Study (n=398 cases+796 control subjects), and the Copenhagen Ischemic Heart Disease Study (n=4901 cases+9798 control subjects) for the R103C, R287Q, and Arg(402-403ins) variants in the EPHX2 gene and recorded hospital admissions due to ischemic stroke, myocardial infarction, and ischemic heart disease.
|
19940276 |
2010 |
|
rs17105278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This longitudinal study thus analyses whether four common polymorphisms (rs2155209, rs7963551, rs17105278, rs2735383) in four selected DSB repair genes (MRE11A, RAD52, RAD51B, NBS1) influence the hazard of age-adjusted death in a cohort of patients with typical symptoms of ischemic heart disease.
|
29024686 |
2017 |
|
rs1740073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
|
rs1764391
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the association between the C1019 > T (Pro319 > Ser) variant of the Cx37 gene and IHD in patients in the Czech Republic, Croatia, Hungary and Romania with regard to the presence/absence of selected cardiovascular risk factors (RF).
|
26588185 |
2016 |
|
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease.
|
25927599 |
2015 |
|
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Among those who died, the incidence of ischemic heart disease and cerebrovascular disease in cases with R213G was significantly higher than in cases without R213G.
|
10720891 |
2000 |
|
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Previously, R213G heterozygosity has been associated with a decreased risk of chronic obstructive pulmonary disease (COPD) and an increased risk of ischemic heart disease (IHD).
|
26901385 |
2016 |
|
rs1799895
|
|
|
0.040 |
GeneticVariation |
BEFREE |
An R213G single nucleotide polymorphism (SNP) has been shown to alter levels of EC-SOD and patient outcomes in chronic obstructive pulmonary disease (COPD) and ischemic heart disease.
|
18948423 |
2009 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aims to determine whether the two major mutations of the haemochromatosis (HFE) gene (C282Y and H63D) are associated with ischaemic heart disease (IHD) or myocardial infarction (MI).
|
12923017 |
2003 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Using robust family-based association tests specifically designed for the study of complex diseases, we found no evidence that the G894T polymorphism of the eNOS gene has a significant role in the development of IHD in our population.
|
15523316 |
2004 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The GluAsp or AspAsp genotype of the Glu298Asp polymorphism was significantly associated with IHD, but not albuminuria in these Japanese diabetic subjects.
|
18243394 |
2008 |
|
rs1799983
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this context, a genetic association study was carried out between two eNOS polymorphisms (the ecNOS4a/b VNTR and the G894T substitution) in a sample of 101 nuclear families having one affected offspring of ischemic heart disease (IHD).
|
12503100 |
2003 |
|
rs1800206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association between the leucine 162 to valine (L162V) polymorphism and a G to C transversion in intron 7 of the PPARalpha gene and progression of atherosclerosis in the Lopid Coronary Angiography Trial (LOCAT), a trial examining the effect of gemfibrozil treatment on progression of atherosclerosis after bypass surgery and on risk of IHD in the second Northwick Park Heart Study (NPHS2), a prospective study of healthy middle-aged men in the United Kingdom.
|
11914252 |
2002 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Leu(10)-->Pro (codon 10) polymorphism in the TGF-beta1 gene is associated with end-stage heart failure caused by dilated CMP and not with IHD.
|
11557193 |
2001 |